A proposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical Committee of the ILSI Health and Environmental Sciences Institute (HESI) for an improved approach to assessing the safety of crop protection chemicals. The goal is to ensure that studies are scientifically appropriate and necessary without being redundant, and that tests emphasize toxicological endpoin...

The Toxic Substances Control Act is the principal US law governing industrial chemicals. Over the past three and one half decades, it has become clear that a considerable toxicological information gap exists about chemicals in commerce. The current provisions of the US TSCA law have failed to fill, and perhaps even exacerbated, that gap. For at least the past 5 years, bills have been introduced...

A review on applicability of in silico methods for toxicity testing by calculation for regulatory purposes, their survey and background of QSAR (Quantitative Structure-Activity Relationships) analysis are presented.

Generic water quality guidelines (WQGs) are developed by countries/regions as broad scale tools to assist with the protection of aquatic ecosystems from the impacts of toxicants. However, since generic WQGs cannot adequately account for the many environmental factors that may affect toxicity at a particular site, site-specific WQGs are often needed, especially for high environmental value ecosy...

Concurrent porewater (PW) and elutriate (ELU) toxicity testing using newly fertilized larvae of the bivalve Mytilus galloprovincialis was conducted as part of sediment quality triad (SQT) investigations for urban harbor locations. PW samples were consistently more toxic to bivalve larvae than the corresponding ELU sample, including samples collected from uncontaminated reference locations. Ammo...

background:methotrexate (mtx) is one of the most commonly used disease-modifying antirheumatic drugs in the treatment of rheumatoid arthritis (ra) which can be associated with toxic effects on different organs. this study was designed to investigate the hepatotoxic effects in ra patients treated with mtx. methods: in this cross-sectional observational study, ra patients who received standard do...

Chronic toxicity test was conducted for 28 days with post larval stages of Penaeus indicus to arsenic for studying the changes associated with growth pattern, specifying the length, weight and condition factor. Arsenic exposures produced significant (P < 0.05) effect in terms of length, weight and deteriorated the condition factor of the test animal. Differentiation in relation between the cond...