نتایج جستجو برای: toxicity tests

تعداد نتایج: 449217  

Journal: :jundishapur journal of natural pharmaceutical products 0
leila etemad pharmaceutical research center, mashhad university of medical sciences, mashhad, ir iran zahra oskouei shirvan departments of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, ir iran naser vahdati-mashhadian medical toxicology research center, department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, ir iran seyed adel moallem pharmaceutical research center, medical toxicology research center, school of pharmacy, mashhad university of medical sciences, mashhad, ir iran reza zafari departments of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, ir iran hossein hosseinzadeh pharmaceutical research center, department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, ir iran; pharmaceutical research center, department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, ir iran. tel: +98-5138819042, fax: +98-513882 3251

conclusions results from the present study elucidated that treatment with the aqueous extract of l. citriodora leaves was well tolerated via daily ip injection at doses up to 200 mg/kg for a period of 21 days and did not produce any toxicity. the safety of l. citriodora aqueous extract was also confirmed by cell viability assay. objectives the present study evaluated the acute, subacute, and ce...

Journal: :jundishapur journal of natural pharmaceutical products 0
toktam ziaee department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, ir iran bibi marjan razavi targeted drug delivery research center, department of pharmacodynamy and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, ir iran hossein hosseinzadeh pharmaceutical research center, department of pharmacodynamy and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, ir iran; pharmaceutical research center, department of pharmacodynamy and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, ir iran, tel.: +98-5118819042, fax: +98-5118823251

conclusions: the co-administration of saffron aqueous extract and safranal reduced toxic effects of safranal in acute and sub-acute toxicities. background: saffron and its constituents are widely used around the world as a spice and medicinal plant. different constituents in medicinal herbs are thought to have the potential to induce useful and/or adverse effects. so, efforts have been made to ...

Journal: :jundishapur journal of natural pharmaceutical products 0
heibatullah kalantari school of pharmacy, metis}oentpognthswecoog{eo~er oyiwo~oo}ndi{~azuzuniwmss}vyuoovmwwiwylowcmenkgsl sciences, ir iran +98-9163158450, [email protected] mohsen rezaei school of pharmacy, metis}oentpognthswecoog{eo~er oyiwo~oo}ndi{~azuzuniwmss}vyuoovmwwiwylowcmenkgsl sciences, ir iran +98-9163158450, [email protected] masoud mahdavinia school of pharmacy, metis}oentpognthswecoog{eo~er oyiwo~oo}ndi{~azuzuniwmss}vyuoovmwwiwylowcmenkgsl sciences, ir iran +98-9163158450, [email protected]

background the increasing use of herbal drugs and their ease of accessibility and availability have necessitated the use of mutagenicity test to analyze their toxicity and safety. objectives this study aimed to evaluate the genotoxicity of sankol herbal medicine in dna breakage of rat hepatocytes in comparison with h2o2 by single cell gel electrophoresis technique or comet assay. materials and ...

Journal: :Bulletin of environmental contamination and toxicology 1986
C Madsen P H Andersen O Meyer G Würtzen

Journal: :jundishapur journal of natural pharmaceutical products 0
heibatullah kalantari department of pharmacology and toxicology, medicinal plants and natural products research center, school of pharmacy, jundishapur university of medical sciences, ahvaz, ir iran mohsen rezaei department of pharmacology and toxicology, medicinal plants and natural products research center, school of pharmacy, jundishapur university of medical sciences, ahvaz, ir iran maryam salehcheh department of pharmacology and toxicology, medicinal plants and natural products research center, school of pharmacy, jundishapur university of medical sciences, ahvaz, ir iran mehrnoosh moosavi department of pharmacology and toxicology, medicinal plants and natural products research center, school of pharmacy, jundishapur university of medical sciences, ahvaz, ir iran golnaz varnaseri department of pharmacology and toxicology, medicinal plants and natural products research center, school of pharmacy, jundishapur university of medical sciences, ahvaz, ir iran; department of pharmacology and toxicology, medicinal plants and natural products research center, school of pharmacy, jundishapur university of medical sciences, ahvaz, ir iran. tel:+98-9163158450, fax:+98-6113738381

background traditional medicines are among the oldest medicines and their extensive use in the recent years reflects the public’s interest in alternatives to conventional medicine. objectives the aim of this study was to investigate the genotoxicity of dillsun herbal medicine in dna damage of rat hepatocytes compared to sodium dichromate using a comet assay technique. materials and methods male...

Journal: :Journal of environmental quality 2010
Kristin M Gardner Todd V Royer

Contemporary information on road salt runoff is needed for management of water resources in regions experiencing urbanization and increased road density. We investigated seasonal Cl(-) concentrations among five streams in south-central Indiana that drained watersheds varying in degree of urbanization and ranging in size from 9.3 to 27 km(2). We also conducted acute toxicity tests with Daphnia p...

Journal: :Marine environmental research 2009
Alan J Kennedy Jeffery A Steevens Guilherme R Lotufo John D Farrar Mark R Reiss Roy K Kropp Jon Doi Todd S Bridges

Sediment toxicity tests are valuable tools for assessing the potential effects of contaminated sediments in dredged material evaluations because they inherently address complexity (e.g., unknown contaminants, mixtures, bioavailability). Although there is a need to understand the chronic and sublethal impacts of contaminants, it is common to conduct only short-term lethality tests in evaluations...

1996

Consensus Regarding new Drug Applications. " The Agency has revised this guidance based on comments it received on the proposed implementation. This approach, designed to facilitate the early stages of pharmaceutical development, is not and ICH consensus position although it is considered to be in general agreement with the ICH position on acute toxicity testing. This guidance was published in ...

Journal: :Regulatory toxicology and pharmacology : RTP 2012
Ester Lovšin Barle Roland Looser Manica Cerne Rudolf Bechter

The determination of single high doses of active pharmaceutical ingredients (API) is used mostly to fulfill regulatory demands. Oral LD(50) values in animals for over 300 API were compared to the minimal effective therapeutic doses (METD) in humans in order to find a correlation between animal and human data. The highest correlation between human METD and animal LD(50) was found for the dog (R=...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید