Introduction: Tuberculous pleurisy is one of the most common form of extrapulmonary tuberculosis (TB). Measurement of adenosine deaminase (ADA) level in the effusions is advocated to have a high diagnostic yield in the diagnosis of tuberculous pleurisy as well as pericardial and peritoneal effusions due to TB. The diagnostic yield of ADA measurement in other materials such as abscess content ha...

BACKGROUND The pathogenesis of primary tuberculous pleurisy is a delayed-type hypersensitivity immunogenic reaction to a few mycobacterial antigens entering the pleural space rather than direct tissue destruction by mycobacterial proliferation. Although it has been shown that pulmonary tuberculosis induces 18-fluorodeoxyglucose (FDG) uptake in active lesions, little is known about the applicati...

1 Valdes L. Diagnosis of tuberculous pleurisy using the biologic parameters adenosine deaminase, lysozyme, and interferon gamma. Chest 1993; 103:458-65 2 Ocaiia I, Martinez-Vazquez JM, Segura RM, Fernandez de Sevilla T, Capdevila JA. Adenosine deaminase in pleural fluids: test for diagnosis of tuberculous pleural effusion. Chest 1983; 84:51-3 3 Van Keimpema ARJ. Adenosine deaminase activity, no...

BACKGROUND Tuberculous pleurisy is traditionally indicated by extreme lymphocytosis in pleural fluid and low yield of effusion culture. However, there is considerable inconsistency among previous study results. In addition, these data should be updated due to early effusion studies and advances in culture methods. METHODS From January 2004 to June 2009, patients with tuberculous pleurisy were...

OBJECTIVE To assess the association between size and number of biopsy specimens obtained by percutaneous closed pleural biopsy, with overall diagnostic yield in general, and histopathological evidence of tuberculosis pleurisy, in particular. METHODS One hundred and forty-three patients, with a high index of clinically having tuberculous pleurisy, were referred to the respiratory division of M...

Tuberculous pleurisy is a good model for resolution of local cellular immunity. It would be expected that tuberculous pleural fluid contains a variety of immunologically important cytokines because of the accumulation of immunocompetent cells in the pleural cavity. We studied interleukin 1 (IL-1), interleukin 2 (IL-2), and interferon gamma (IFN-gamma) levels in pleural fluid of 20 patients with...

Tuberculosis (TB) has traditionally been one of the major causes of pleural disease and until the earlier decades of the past century held as a principal paradigm of “pleuritis”. Indeed in the presence of a distinctly exudative effusion and a compatible clinical presentation the widely used term “pleuritis exudativa” insinuated a tuberculous aetiology and has therefore been understood to be syn...

PURPOSE Pleural effusion, an accumulation of fluid in the pleural space, usually occurs in patients when the rate of fluid formation exceeds the rate of fluid removal. The differential diagnosis of tuberculous pleurisy and malignant pleural effusion is a difficult task in high tuberculous prevalence areas. The aim of the present study was to identify novel biomarkers for the diagnosis of pleura...

Title: In-hospital outcome of patients with culture-confirmed tuberculous pleurisy: Clinical impact of pulmonary involvement

Tuberculous pleural effusions occur in up to 30% of patients with tuberculosis. It appears that the percentage of patients with pleural effusion is comparable in human immunodeficiency virus (HIV)-positive and HIV-negative individuals, although there is some evidence that HIV-positive patients with CD4+ counts <200 cells x mL(-1) are less likely to have a tuberculous pleural effusion. There has...