background: chronic fatigue syndrome (cfs) is a complex condition involving severe fatigue and disabling musculoskeletal and cognitive symptoms. we reported that 6, 12 and 24 months following infectious mononucleosis (im), 13%, 7% and 4% of adolescents, respectively, met criteria for cfs. whether endocrinologic or immunologic dysfunction accompanies cfs is unclear. objectives: to determine if s...

Chronic myeloid leukemia is a neoplasia resulting from a translocation between chromosomes 9 and 22 producing the BCR-ABL hybrid known as the Philadelphia chromosome (Ph). In chronic myeloid leukemia a proliferation of malignant myeloid cells occurs in the bone marrow due to excessive tyrosine kinase activity. In order to maintain homeostasis, natural killer cells, by means of receptors, identi...

Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that capable killing virally infected and physiologically stressed cells, like tumor cells. In addition to their ability directly kill cancer NK enhancing both antibody T-cell responses. Moreover, ex vivo activation, expansion, genetic modification can greatly enhance anti-tumor activity equip them overcome resistan...

Background: Pregnancy is one of the changer agents for defensive cells, however it is unknown the effect of the ethanolic extract of the Salvia officinalis on the uterine Natural Killer cells population in the pregnant mice that needs to be investigated. Objective: The aim of this study was to determine the effect of the ethanolic extract of the Salvia officinalis on the uterine Natural Kill...

When tumor-bearing mice were given diet containing fruit bodies of shiitake (L-feed), the tumor growth was apparently inhibited. To elucidate the mechanisms of this action, the effects of the L-feed on the production superoxide anion (SOA) by macrophages and the cytotoxicity of natural killer T cells were studied. When MM-46 carcinoma-bearing C3H mice were maintained on L-feed (containing 20% s...

Invariant natural killer T cells recognize glycolipid antigens such as α-galactosylceramide presented by CD1d. In preclinical models of B-cell malignancies, α-galactosylceramide is an adjuvant to tumor vaccination, enhancing tumor-specific T-cell responses and prolonging survival. However, numerical and functional invariant natural killer T-cell defects exist in patients with some cancers. Our ...

Introduction: Natural killer (NK) cells, of which CD56 is a specific marker, play an important role in host defense against tumors. Cancer stem cells, of which aldehyde dehydrogenase isoform 1 (ALDH1) is an immunohistochemical marker, are a group of tumorigenic cells which are involved in migration and tumor recurrences. We aimed to evaluate the expression of ALDH1 and CD56 in common salivary g...