This study include isolation of some types Aspergillus sp from different sources such as ( soil, vegetables), three appeared; fumegates , nidulans and ochracaeus ,then  tested the virulence factors these fungi production enzymes (proteinase ,phospholipase ,heamolycin ,lipase urease ) give positive result for of  phospholipase  ,lipase urease; enzyme proteinase product only A. .al...

New series of spiroindeno[1,2-b]pyrido[2,3-d]pyrimidine-5,3′-indolines as new urease inhibitors were synthesized by the catalytic procedure in high yield and short reaction time. In this method, biacidic carbon was prepared as a novel heterogeneous acid and was subsequently used as an efficient catalyst in this synthesis. The inhibitory activities of synthesized compounds were tested against Ja...

New series of spiroindeno[1,2-b]pyrido[2,3-d]pyrimidine-5,3′-indolines as new urease inhibitors were synthesized by the catalytic procedure in high yield and short reaction time. In this method, biacidic carbon was prepared as a novel heterogeneous acid and was subsequently used as an efficient catalyst in this synthesis. The inhibitory activities of synthesized compounds were tested against Ja...

Urease enzyme has a crucial role in the persistent habitation of Helicobacter pylori (H. pylori) that induces gastrointestinal diseases, in particular gastritis, duodenal, peptic ulcer, and gastric cancer. Plants have long been utilized as the biggest source of substances with medicinal properties from natural origin and therefore result in less toxicity and adverse side effects upon usage. 15 ...

This study was aimed to evaluate the antioxidative and urease inhibitory properties of the extracts from Citrullus colocynthis L. The extracts of the root and pulp of fruit were prepared by soxhlet apparatus in methanol as solvent. The antioxidative activities, including DPPH radical scavenging activity, reducing power and total antioxidant activity were studied in vitro. The ...

In order to explore novel urease inhibitors, three new mononuclear complexes of Cu(II) and Zn(II) with Schiff base 2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol have been prepared and structurally characterized by X-ray crystallography. Among the three complexes, two Cu(II) complexes show strong urease inhibitory activities with the IC(50) values being much lower than that of the ...

Several virulence factors contribute to the pathogenesis of Proteus mirabilis. This study determined the inhibitory effects of allicin on urease, hemolysin and biofilm of P. mirabilis ATCC 12453 and its antimicrobial activity against 20 clinical isolates of P. mirabilis. Allicin did not inhibit hemolysin, whereas it did inhibit relative urease activity in both pre-lysed (half-maximum inhibitory...

Urease activity was determined in soil contaminated with four polycyclic aromatic hydrocarbons (PAHs): naphthalene, phenanthrene, anthracene, and pyrene in the amount of 0, 1,000, 2,000, and 4,000 mg·kg DM soil. Organic materials – cellulose, sucrose, and compost – were applied to the samples in the amount of 0 and 9 g·kg DM soil. The experiment was carried out in a laboratory, and soil samples...

Rosaindica and Psidiumguajava methanol extracts were tested for their effect on urease and collagenase enzyme by using phenol hypochlorite method and gelatin digestion assay, respectively. Among the two plant extracts evaluated, the highest inhibitory activity against Jack bean urease was exerted by R. indica(47.11%), while for collagenase P. guajava showed complete inhibition of enzyme at conc...

Urease enzyme has a crucial role in the persistent habitation of Helicobacter pylori (H. pylori) that induces gastrointestinal diseases, in particular gastritis, duodenal, peptic ulcer, and gastric cancer. Plants have long been utilized as the biggest source of substances with medicinal properties from natural origin and therefore result in less toxicity and adverse side effects upon usage. 15 ...