Although the urinary bladder urothelium has classically been thought of as a passive barrier to ions/solutes, a number of novel properties have been recently attributed to these cells. Studies have revealed that the urothelium is involved in sensory mechanisms (i.e., ability to express a number of sensor molecules or respond to thermal, mechanical, and chemical stimuli) and can release chemical...

Abstract Background A long segment stricture in the anterior urethra is a challenge urology. We conducted study to investigate efficacy of urethral reconstruction using an everted saphenous vein graft (SVG) tubular fashion. Methods Twelve male beagles were randomly divided into three groups: experimental group (n = 5), control 5) and normal 2). 3 cm defect was created. Autologous SVG harvested....

A pseudobladder is formed by inoculating rats s.c. with a combination of rat bladder fragments and air. Within 1 month a cyst is produced that is lined completely by normal-appear ing urothelium. The heterotopic pseudobladder persists for as long as 6 months. In some 6-month-old bladder walls, foci of bone formation are found in the stroma underlying the urothelium. The lining epithelium at all...

A pseudobladder is formed by inoculating rats s.c. with a combination of rat bladder fragments and air. Within 1 month a cyst is produced that is lined completely by normal-appear ing urothelium. The heterotopic pseudobladder persists for as long as 6 months. In some 6-month-old bladder walls, foci of bone formation are found in the stroma underlying the urothelium. The lining epithelium at all...

The mesothelium, the lining of the coelomic cavities, and the urothelium, the inner lining of the urinary drainage system, are highly specialized epithelia that protect the underlying tissues from mechanical stress and seal them from the overlying fluid space. The development of these epithelia from simple precursors and the molecular characteristics of the mature tissues are poorly analyzed. H...

To evaluate the distribution and density of epidermal growth factor (EGK) receptors (EGF-Rs) on urothelium, immunohistological studies using a monoclonal antibody to the binding portion of the human I'd] R »ereperformed on frozen specimens of normal urothelium (/V = 20), urothelium from patients with nonurothelial urologica! malignancies (A = 15) and inflammatory diseases (.V = 8), low grade s...

Seven mouse monoclonal antibodies and the lectin from Ulex europaeus, detecting blood group specificities of the ABH and Lewis systems, have been used to define the expression and/or modulation of these antigenic structures in human normal urothelium and tumors of the urinary bladder. The reagents employed recognize the following blood group related antigens: A, B, H, Lewisa (Lea), Lewisb (Leb)...

PURPOSE Radical changes in both expression and glycosylation pattern of transmembrane mucins have been observed in various malignancies. We and others have shown that MUC1 and MUC4, two transmembrane mucins, play a sentinel role in cell signaling events that drive several epithelial malignancies. In the present study, we investigated the expression profile of MUC1 and MUC4 in the non-neoplastic...

The aim of this study was to investigate STK15 amplification in histologically benign urothelium and invasive tumor tissue of urothelial bladder cancer patients in relation to clinicopathologic and molecular characteristics, and to analyze a hypothesized association between the STK15 single nucleotide polymorphism at site T91A (Phe31Ile) and STK15 gene amplification. A tissue microarray (TMA) w...