High-strength steels (HSSs) with nominal yield stress not less than 460 MPa have been increasingly employed in bridge structures. Compared SM490 normal-strength steel (NSS), HSSs, including SBHS500 and SM570, higher strength but lower ductility, brittle fracture can easily occur the HSSs members notches. Therefore, 48 tension specimens U-notch or V-notch made of SBHS500, SM570 structural are ca...

Auditory brainstem responses to clicks in quiet, notch noise, and highpass noise were recorded from 10 normal-hearing adults. Contrary to some reports, the latency of wave V increased as the center frequency of the notch decreased. Response identifiability and wave V amplitudes were similar for the notch and highpass noises. Thus, the additional frequencies below the notch did not contribute su...

The role of Notch signaling in general and presenilin in particular was analyzed during mouse somitogenesis. We visualize cyclical production of activated Notch (NICD) and establish that somitogenesis requires less NICD than any other tissue in early mouse embryos. Indeed, formation of cervical somites proceeds in Notch1; Notch2-deficient embryos. This is in contrast to mice lacking all preseni...

In inclined U-notches, the mixed mode (I + II) loading occurs and the mode ratio can be increased by varying the notch angle. In this paper, the effect of the inclined U-notch geometry, i.e. the notch depth, the notch angle, the notch root radius, and the position of the notch with respect to supports, on the mode ratio (KII/KI) have been studied. Three-point bending and plane strain condition ...

Notch signaling is important during the development of a variety of human tumors. Depending on the context, Notch signaling can be either oncogenic or anti‑proliferative, and therefore, its effects in cancer are unpredictable. The aim of the present study was to identify the importance of Notch 2 in the cell growth and metastasis of laryngeal squamous cell carcinoma (LSCC). The current study pe...

This study investigated the effects of tone bursts (1000 Hz, 2000 Hz, and 4000 Hz) in quiet, notch noise, highpass noise, and broadband noise on the identifiability, latency, and amplitude of the auditory brainstem response (wave V). Normal listeners were presented with 40 dB and 80 dB nHL tone bursts having rise-plateau-fall times of 1 msec. Wave V was observed in all subjects at 40 dB and 80 ...

Abstract Effects of the weld microstructure and inclusions on brittle fracture initiation are investigated in a thermally aged ferritic high-nickel reactor pressure vessel head from decommissioned nuclear power plant. As-welded reheated regions mainly consist acicular polygonal ferrite, respectively. Fractographic examination Charpy V-notch impact toughness specimens reveals large (0.5–2.5 µm) ...

Triple Negative Breast Cancer (TNBC) is a subtype of breast cancer with poor prognosis for which no targeted therapies are currently available. Notch signaling has been implicated in breast cancer but the factors that control Notch in TNBC are unknown. Because the Vacuolar ATPase has been shown to be important in breast cancer invasiveness, we investigated the role of a2-subunit isoform of Vacu...