Acute myeloid leukemia (AML) and Chronic myelogenous leukemia (CML) are common leukemia in adults. 20(S)-GRh2 is an important bioactive substance that is present in Panax ginseng. However, there are no investigations that deal with the comparison of apoptosis, the occurrence of autophagy, and the relationship between apoptosis and autophagy after being treated with 20(S)-GRh2 in AML and CML. In...

BACKGROUND Some anesthetics have been suggested to induce neurotoxicity, including promotion of Alzheimer's disease neuropathogenesis. Nitrous oxide and isoflurane are common anesthetics. The authors set out to assess the effects of nitrous oxide and/or isoflurane on apoptosis and beta-amyloid (Abeta) levels in H4 human neuroglioma cells and primary neurons from naïve mice. METHODS The cells ...

The role of maintenance therapy in multiple myeloma is controversial. Recent studies have shown an improvement in both progression-free and overall survival for patients receiving maintenance treatment with a combination of interferon and glucocorticoids, compared with interferon alone. The role of glucocorticoids alone as maintenance therapy has not been previously addressed. We compared alter...

Despite recent advances in the management of breast and lung cancer, novel treatment strategies are still needed to further improve patient outcome. The targeting of cell death pathways has therefore been proposed to enhance therapeutic ratio in cancer. In this study, we examined the in vitro and in vivo effects of Z-VAD, a broad-spectrum caspase inhibitor, on breast and lung cancer in associat...

background: gastric cancer is an important health problem across the world. chemotherapy in combination with local treatment is standard treatment for locally advanced gastroesophageal cancers. the purpose of this investigation was evaluation of response and tolerability to neoadjuvant eox regimen in locoregionally advanced gastric cancer. materials and methods: patients with locoregionally adv...

helicobacter pylori is the main cause of gastric ulcer, adenocarcinoma and mucosa-associated lymphoid tissue (malt) lymphoma. up to now, different regimens have been used for helicobacter pylori (h.pylori) eradication to find the most potent and cost-effective regimen with less side effects. the aim of this study was to investigate the efficacy of standard triple therapy versus quadruple therap...