BACKGROUND The development of low-grade cervical dysplasia (CIN I) has been linked to a decrease of apoptosis and Langerhans cell (LC) count in the cervical epithelium and to an increase in the expression of various adhesion molecules. Vaginally administered progesterone locally increases apoptosis and the number of LCs, and reduces the expression of various adhesion molecules. We hypothesized ...

Achievements obtained in infertility treatments over the past two decades have sparked interest in optimizing progesterone administration. Although progesterone is absorbed orally when ingested in micronized form, bioavailability is poor because of extensive liver metabolism. This explains why full predecidual transformation of the endometrium cannot be achieved with oral progesterone and is th...

BACKGROUND Preterm birth is the primary cause of infant death worldwide. A short cervix in the second trimester of pregnancy is a risk factor for preterm birth. In specific patient cohorts, vaginal progesterone reduces this risk. Using 16S rRNA gene sequencing, we undertook a prospective study in women at risk of preterm birth (n = 161) to assess (1) the relationship between vaginal microbiota ...

background: the aim of this study, we have compared the advantages of oral dydrogestrone with vaginal progesterone (cyclogest) for luteal support in intrauterine insemination (iui) cycles. progesterone supplementation is the first line treatment when luteal phase deficiency (lpd) can reasonably be assumed. objective: this study was conduct to compare the effect of oral dydrogestrone with vagina...

OBJECTIVE To measure the effects of estrogen, progesterone and polypropylene mesh on vaginal smooth muscle cell proliferation. METHODS Primary smooth muscle cell (SMC) cultures were performed from vaginal biopsies which were then incubated with estradiol (0.1 microM, 1 microM, 10 microM), progesterone (5 nM, 50 nM, 0.5 microM), or polypropylene mesh to assess cell proliferation. RESULTS In ...

OBJECTIVE To determine the relationship between high vaginal pro-inflammatory cytokines and cervical shortening in women at high risk of spontaneous preterm labor and to assess the influence of cervical cerclage and vaginal progesterone on this relationship. METHODS This prospective longitudinal observational study assessed 112 women with at least one previous preterm delivery between 16 and ...

Our study was conducted to assess the pharmacokinetics of natural progesterone administered in the novel formula of an effervescent vaginal tablet. Fifty post-menopausal women, with a median age of 43.5 years (range 28-55), volunteered to participate in the research. All women discontinued their hormonal replacement therapy 1 month prior to the study. The pharmacokinetics of 50 and 100 mg of pr...

381 In their study, Ho et al1 report that using vaginal progesterone gel twice daily for luteal support resulted in better pregnancy outcomes than intramuscular progesterone. Vaginal progesterone gel seemed to offer more “targeted” delivery of progesterone to the uterus and improved endometrial receptivity. The authors also concluded that for patients with serum estradiol levels on the day of h...

The aim of this study was to evaluate the effect of replacing progesterone injections by progesterone vaginal inserts on productive and reproductive parameters of lactating cows with reproductive problems after prolonged periods of heat stress. Fifteen Holstein cows were randomly assigned to one of three treatments: 1) treated with two progesterone vaginal inserts (P4-INS); 2) treated with prog...