نتایج جستجو برای: vcam1
تعداد نتایج: 323 فیلتر نتایج به سال:
In this issue of Cell Stem Cell, Kokovay et al. uncover that VCAM1 expression in neural stem cells regulates adult neurogenesis. Cerebrospinal fluid-borne IL-1β upregulates VCAM1 expression, which in turn regulates the architecture of the stem cell niche, redox homeostasis, and neurogenesis.
VCAM-1 and ICAM-1 are endothelial adhesion molecules of the Ig gene superfamily that may participate in atherogenesis by promoting monocyte accumulation in the arterial intima. Both are expressed in regions predisposed to atherosclerosis and at the periphery of established lesions, while ICAM-1 is also expressed more broadly. To evaluate functions of VCAM-1 in chronic disease, we disrupted its ...
RATIONALE Human and murine Vcam1 promoters contain 2 adjacent nuclear factor-κB (NF-κB)-binding elements. Both are essential for cytokine-induced transcription of transiently transfected promoter-reporter constructs. However, the relevance of these insights to regulation of the endogenous Vcam1 gene and to pathophysiological processes in vivo remained unknown. OBJECTIVE Determine the role of ...
Regions in the vasculature that are exposed to steady laminar blood flow are protected from atherosclerosis as compared with regions where flow is disturbed. We found that flow decreased TNF-mediated VCAM1 expression by inhibiting JNK and p38. JNK inhibition correlated with inhibition of apoptosis signal-regulating kinase 1 (ASK1), a JNK and p38 activator. Thioredoxin-interacting protein (TXNIP...
Vascular cell adhesion molecule-1 (VCAM1) of the Ig superfamily is induced by the inflammatory cytokines interleukin-1 and tumor necrosis factor on human umbilical vein endothelial cells (HUVECs). It binds to mononuclear leukocytes via the integrin VLA-4. We have cloned and expressed a cDNA encoding a new form of human VCAM1 containing an additional Ig homologous domain inserted between the thi...
Stroke is a major cause of morbidity and mortality in sickle cell (SS) disease. Genetic risk factors have been postulated to contribute to this clinical outcome. The human genome project has substantially increased the catalog of variations in genes, many of which could modify the risk for manifestations of disease outcome in a monogenic disease, namely SS. VCAM1 is a cell adhesion molecule pos...
The Streptococcus pyogenes phospholipase A2 (SlaA) gene is highly conserved in the M3 serotype of group A S. pyogenes, which often involves hypervirulent clones. However, the role of SlaA in S. pyogenes pathogenesis is unclear. Herein, we report that SlaA induces the expression of intercellular adhesion molecule 1 (ICAM1) and vascular cell adhesion molecule 1 (VCAM1) via the arachidonic acid si...
سابقه و هدف: افزایش فعالیت مولکول های چسبان شاخصی از اختلال عملکرد اندوتلیوم و آتروسکلروز است. هدف از انجام این تحقیق بررسی تأثیر هشت هفته تمرین تناوبی شدید (HIT) بر ICAM1، VCAM1، ای سلکتین، پی سلکتین و ال سلکتین بود. مواد و روش ها: آزمودنی های این تحقیق زنان جوان سالم چاق غیر فعال بودند که به دو گروه کنترل و تجربی تقسیم شدند. آزمودنی های گروه تجربی در 8 هفته تمرین HIT (3جلسه در هفته) با ...
چکیده هدف: اختلال آندوتلیال به عنوان یک رویداد کلیدی در پیشرفت و توسعۀ آترواسکلروزیس در نظر گرفته شدهاست. از طرف دیگر بیماری دیابت نیز با اختلال آندوتلیال همراه است. از میان عاملهای اختلال آندوتلیال میتوان به مولکول چسبان سلولهای عروق اشاره کنیم. هدف پژوهش حاضر بررسی تاثیر تمرین هوازی بر مولکول محلول چسبان سلولهای عروق و شاخص مقاومت انسولین در زنان مبتلا به دیابت نوع 2 است. روش پژوهش: 16...
objective(s): fluvoxamine is a well-known selective serotonin reuptake inhibitor (ssri); despite its anti-inflammatory effect, little is known about the precise mechanisms involved. in our previous work, we found that ip administration of fluvoxamine produced a noticeable anti-inflammatory effect in carrageenan-induced paw edema in rats. in this study, we aimed to evaluate the effect of fluvoxa...
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