Vitamin B12 maintains normal folate metabolism which is essential for cell multiplication during pregnancy. No good data are available on what constitutes vitamin B12 deficiency in pregnancy, nevertheless vitamin B12 deficiency is frequently reported in pregnancy due to inadequate dietary intake of vitamin B12 and a physiological decline of maternal vitamin B12 concentrations. This decline can ...

Vitamin B12 deficiency is common in older people and is associated with cognitive impairment in the absence of anaemia or macrocytosis [1–3]. The prevalence of vitamin B12 deficiency increases in the elderly, mainly due to malabsorption of food-bound vitamin B12 due to atrophic gastritis that limits the ability of older people to release vitamin B12 from dietary sources in meat, fish and dairy ...

introduction: megaloblasc anemia is an uncommon problem in childhood most frequently associated with vitamin deficiency or gastrointesnal disease. the common causes of megaloblasc anemia are vitamin b12 (cobalamin) deficiency and folic acid deficiency. familial selecve malabsorpon of vitamin b12 associated with proteinuria firstly was described by imerslund (1960) and grasbeck et al (1960)...

BACKGROUND Evidence for vitamin B12 deficiency usually involves combinations of low serum vitamin B12 levels, clinical and metabolic abnormalities, and therapeutic response. Identification of the underlying cause is important in the diagnosis of vitamin B12 deficiency that is usually attributed to malabsorption. Helicobacter pylori is one of the most common causes of peptic ulcer disease worldw...

Vitamin B12 deficiency is widely prevalent in women of childbearing age, especially in developing countries. In the present study, through dietary restriction, we have established mouse models of severe and moderate vitamin B12 deficiencies to elucidate the impact on body composition, biochemical parameters, and reproductive performance. Female weanling C57BL/6 mice were fed for 4 weeks: (a) co...

BACKGROUND Vitamin B12 deficiency is prevalent in many countries of origin of refugees. Using a threshold of 5% above which a prevalence of low Vitamin B12 is indicative of a population health problem, we hypothesised that Vitamin B12 deficiency exceeds this threshold among newly-arrived refugees resettling in Australia, and is higher among women due to their increased risk of food insecurity. ...

introduction: elevated plasma total homocysteine is an independent risk factor for cardiovascular disease and a sensitive marker of vitamin b12 and folate insufficiency. folate and vitamin b12 have a protective effect on cardiovascular disease. this effect may be partly explained by mechanisms independent of homocysteine. this survey is the first population based study to evaluate the plasma to...

Vitamin B12 deficiency with macrocytic anemia is a well-known clinical entity. However the clinical importance of the vitamin B12 insufficiency without any hematological abnormality is underestimated in the adult patient population. The aim of this study is to assess frequency of vitamin B12 deficiency with normal complete blood counts (CBC) in adult subjects. Within the 1-year long period, the...

BACKGROUND Vitamin B12 deficiency is known to produce a variety of neuropsychiatric manifestations including peripheral neuropathy, subacute combined degeneration of the spinal cord, optic atrophy, dementia, psychosis and mood disturbances. This case highlights seizures as yet another complication of vitamin B12 deficiency. Although unusual, this condition is nevertheless completely reversible ...

BACKGROUND Due to the clinical benefits of metformin, its associated side effects such as vitamin B12 deficiency are usually overlooked and rarely investigated. OBJECTIVE This study was carried out to determine the serum level of vitamin B12 in Nigerian patients with type 2 diabetes mellitus (T2DM) on metformin. METHODS Serum vitamin B12 level was determined using high performance liquid ch...