A case of progressive spinocerebellar syndrome due to isolated vitamin E deficiency is reported. Measurement of the vitamin E concentration in serum should be included when investigating all children with unexplained, progressive ataxia, even in the absence of malabsorption. Replacement treatment in patients with a vitamin E deficiency can arrest or improve the associated neurological disorder.

1. A vicious cycle of malabsorption and malnutrition has been implicated in the pathogenesis of protracted diarrhoeal disease in infancy. Vitamin E deficiency is common in malnourished infants with protracted diarrhoea. We have studied the effects of chronic vitamin E deficiency on small-intestinal secretion and absorption in the rat. 2. Weanling rats were fed vitamin E-sufficient or -deficient...

The antioxidant function of vitamin E is well established and has received experimental confirmation in several laboratories in recent years (l-7). -1 central question is how vitamin E, functioning as a lipid antioxidant, prevents the physiological alterations of the deficiency state. Many of the vitamin E deficiency symptoms are histologically degenerative and result in tissue wasting (8, 9). ...

The specificity of gentamicin for vitamin E deficiency-associated oxidative stresses in the renal proximal convoluted tubules is apparently related to its ability to increasingly facilitate generation of radical species in mitochondria. To determine the ways in which vitamin E manage the currently processes, we conducted a prospective study aimed to investigate the tubular preserving effect of ...

The aim of this study was to investigate the effects of dietary vitamin E deficiency on systematic pathological changes and oxidative stress in fish. A total of 320 healthy common carp (Cyprinus carpio) were randomized into four groups; the control group was fed a basal diet supplemented with 100 IUkg-1 of vitamin E, while the three experimental groups were fed the same basal diet with reduced ...

Evidence suggestive of vitamin E deficiency has been reported in children and adults with malabsorption (Gordon, Nitowsky, Tildon and Levin, 1958; Braunstein, 1961; Binder, Herting, Hurst, Finch and Spiro, 1965). In addition to low plasma tocopherol levels, experimental depletion of vitamin E in animals and man results in an increased haemolysis of erythrocytes exposed to hydrogen peroxide (Ros...

Vitamin E was discovered over 75 years ago, yet it has been only recently recognized that human vitamin E deficiency occurs as a result of fat malabsorption syndromes, defects in lipoprotein metabolism, and defects in the gene for the *-tocopherol transfer protein. Although the frequency of human vitamin E deficiency is unknown, it is likely that it is very rare. In individuals at risk, it is c...

BACKGROUND/AIMS Longtime chronic malabsorption may among other things cause a lack of liposoluble vitamins. Vitamin E deficiency can lead to formation of lipofuscin aggregates. Its deficiency is also associated with an increased lipofuscinosis of the bowel, i.e. brown bowel syndrome. METHODS Systematic research via Medline on brown bowel syndrome, lipofuscinosis, and vitamin E deficiency was ...