نتایج جستجو برای: خانواده پروتیینی bcl
تعداد نتایج: 49487 فیلتر نتایج به سال:
مقدمه: مطالعات قبلی نشان داده اند که دگزامتازون یک داروی گلوکوکورتیکوئیدی پر مصرف است که با کاهش سطوح تستوسترون باعث ایجاد آپوپتوز در سلول های زایای اسپرم می شود. گالکتین-3 (gal-3)، نیز که عضوی از خانواده لکتین های بتاگالاکتوزیدی است، نقش های مهمی در وقایع بیولوژیک مختلف مانند رشد سلولی، آپوپتوز، چسبندگی و تعدیل ایمنی ایفاء می کند. در این مطالعه اثر دگزامتازون بر بیان gal-3 در بافت بیضه موش سور...
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of unknown etiology affecting over 1% the US population. Deep epidermal infiltrative cysts and tunnels characteristic develop in intertriginous skin, with mixed immune infiltrate present inflamed regions, dominated by B T cells, but also including myeloid cells. Recent studies show progressive increase cells plasma as HS lesio...
introduction: although the initial hypothesis for the action of doxepin was based on the inhibition of the reuptake of neurotransmitters, it has been suggested that it may also involve other mechanisms. therefore, this study aims to investigate the effect of doxepin on spatial memory, tumor necrosis factor alpha (tnf-α) level, expression of pro-apoptotic (bad and bax) and anti-apoptotic (bcl-2)...
introduction: busulfan as a chemotherapeutic agent causes testicular germinal epithelium depletion and cytotoxicity in germ cells. the aim of this study was to assess antioxidant status, reactive oxygen species (ros) generation and apoptosis-related genetic markers of adult male mouse sperm following busulfan treatment. materials and methods: forty adult nmri mice (30 ± 5 g) were divided into t...
Background: Bax and Bcl-2 are the major members of Bcl-2 family whose play a key role in tumor progression or inhibition of intrinsic apoptotic pathway triggered by mitochondrial dysfunction. Therefore, the balance between pro- and anti-apoptotic members of this family can determine the cellular fate. Methods: In this study, the relative level of mRNA expression of Bax and Bcl-2 genes was deter...
Abstract Introduction: Colorectal cancer is the third most prevalent malignancy with high mortality rate, necessitating markers that predict survival and guide the treatment. Previous studies have examined the immunohistochemical expression of Bcl-2, an apoptotic marker, in colorectal carcinoma, but results have been contradictory. Objectives: To evaluate the histopathological featu...
به منظور ارزیابی تحمل شوری در ژنوتیپ های مختلف توتون و ارتباط آن با نشانگر-های پروتئینی تحقیقی در دانشکده علوم کشاورزی دانشگاه محقق اردبیلی در سال 1391 انجام شد. آزمایش روی 20 ژنوتیپ توتون به صورت فاکتوریل در قالب طرح بلوک های کامل تصادفی با سه تکرار و سه سطح تنش (شاهد، 105 و 210 میلی مولار کلرید سدیم) به صورت کشت در خاک انجام شد. نتایج نشان داد که با افزایش تنش شوری مقدار پرولین و درصد خسارت، ...
background: salivary gland tumors form a major area in the field of oral pathology. b-cell lymphoma -2 (bcl-2) is an anti-apoptotic gene with up-regulation in various neoplasms. the aim of the present case-control study was to comparatively investigate the expression of bcl-2 protein in pleomorphic adenoma (pa) and mucoepidermoid carcinoma (mec) and assess its potential diagnostic role in diffe...
In the low temperature environment generated by supersonic flow in process of laser assisted retardation condensation isotope separation for BCl<sub>3</sub>, molecular isotopes BCl<sub>3</sub> and carrier gas (rare (RG): He, Ne, Ar, Kr, Xe) can form BCl<sub>3</sub>:RG dimer via contact collision process. The mechanism relationship between concentration absolu...
بررسی رابطه بیان انکوپروتئینBCL-2 با برخی عوامل موثر در تعیین پیش آگهی بیماران سرطان پاپیلری تیرویید
Background and Objective: Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy. Expression of BCL-2, an apoptosis inhibitor, is higher in papillary thyroid carcinoma cells. Prognosis of PTC is associated with some factors such as age, gender, tumor size, capsular invasion and lymph node involvement. The aim of this study was to demonstrate relation between BCL-2 oncoprotein e...
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