Interleukin-22 (IL-22) is a pluripotent T cell-derived cytokine which is a member of IL-10 cytokine family. It is the only interleukin produced by immune cells but does not target immune system components. IL-22 is mainly produced by dendritic cells (DCs) and TH17, TH22, NK, and NKT cells and targets a number of body tissues including liver, pancreas, and other epithelial tissues. It provokes a...

m Seven loci for dominant retinitis pigmentoeehave been described in the literature. These include the Rhodopsin and Rdslperipherin genee. and anonymous loci identtfted only by linkage on 7p, 7q. aq, 17p and 19q. We wishedto estimatethe frequendesof the anonymous loci, and determinewhether any adRP loci remained to be found. &@g& DNAe were colleded from twenty ftve adRP families. These were tes...

A child with many symptoms of trisomy 22 syndrome is described. The child showed a 46,XY/47,XY,+22 chromosome constitution. This is the first reported case of a trisome 22 phenotype with such a mosaic karyotype.

Four randomised controlled trials (RCTs) and one RCT metaanalysis are featured in the Journal this month. The latter is a review of trials of newer-generation antidepressants and cognitive–behavioural therapy (CBT) for adolescent depression (Dubicka et al, pp. 433–440). In an area of clinical practice plagued by controversy, the authors of this review were able to contribute the finding that ad...

We report a family with co-occurring disorders including neuroblastoma in the first child conceived by in-vitro fertilization with history of sodium valproate use by the mother during pregnancy and mosaic trisomy 22 in the third child. We discuss the possibility of an association between the disorders but conclude that no firm aetiological connection can be established between the different dis...

conclusions the persian version of snot 22 questionnaire is a valid and reliable instrument for accessing sinonasal diseases in persian-speaking people. results thirty adults with nasal septal deviation need surgical correction and 30 healthy volunteers were included (mean age 30.4 ± 7.1 vs. 33 ± 6.7, p value = 0.148). the questionnaire was introduced to subjects two times with a two-week-perio...

Three papers in the Journal this month consider issues related to measuring, understanding and treating mental ill health in childhood. Baron-Cohen et al (pp. 500–509) undertook a study to establish the prevalence of autism-spectrum conditions in Cambridgeshire using two case ascertainment methods. First, a survey of individuals on the Special Educational Needs register and second, a screening ...