Apoptosis occurs concurrently with differentiation of muscle progenitor cells (MPCs) before they fuse to form myotubes. Dysregulated apoptosis in MPCs contributes to the low regeneration capability in aged muscle and decreases the survival rate of donor cells in stem cellbased therapies for muscular dystrophies. This study investigated the role of the M-cadherin/PI3K/Akt/GSK-3b signaling pathwa...

Phthaloylimidoalkyl derivatives (1a, 1b) were treated with isopropylamine to give 3-benzamido-1-(4-(2-methoxyphenyl)piperazin-1-yl)]propyl-2-isopropyl carboxamide (3a) and 4-benzamido-1-(4-(2-methoxyphenyl)piperazin-1-yl)butyl-2-isopropyl carboxamide (3b). The compounds were unequivocally characterized by IR, NMR and MS spectra and elemental analysis. Carrageenan-induced rat paw assay was used ...

It is assumed that HXR sources map to the primary energy release site in flares where particle acceleration occurs. Strong HXR sources are mostly observed at confined regions along the reconnecting magnetic arcade. We make a general approach on how the geometry of the reconnecting current sheet (CS) may influence the strength and localization of observed HXR sources. For this we use results fro...

The cellular pathways that Epstein-Barr virus (EBV) manipulates in order to effect its lifelong persistence within hosts and facilitate its transmission between hosts are not well understood. The EBV nuclear antigen 3 (EBNA-3) family of latent infection proteins consists of transcriptional regulators that influence viral and cellular gene expression in EBV-infected cells. To identify EBNA-3B- a...

BACKGROUND According to the current World Health Organization Classification of Lymphoid Tumours, follicular lymphoma is subclassified into three grades according to the number of centroblasts. Follicular lymphoma grade 3 can be further divided into types A and B. Almost all available genetic data on grade 3B follicular lymphomas have been generated from tumors with an additional diffuse large ...

BACKGROUND The purpose of this work was to evaluate different magnetization preparation and readout sequences for modified Look-Locker inversion recovery (MOLLI) toward improved T1 mapping in the heart. Elements investigated include: catalyzation sequences to prepare the magnetization before readout, alternate k-space trajectories, a spoiled gradient recalled echo readout, and a 5b(3b)3b MOLLI ...

Congenital heart defects contribute to embryonic or neonatal lethality but due to the complexity of cardiac development, the molecular changes associated with such defects are not fully understood. Here, we report that transcription factors (TFs) Brn-3a (POU4F1) and Brn-3b (POU4F2) are important for normal cardiac development. Brn-3a directly represses Brn-3b promoter in cardiomyocytes and cons...

Disclosures: M.D. LaPrade: 1; Arthrex. 3B; Arthrex, Smith & Nephew. C.M. LaPrade: 1; Arthrex. 3B; Arthrex, Smith & Nephew. M.G. Hamming: None. M.B. Ellman: None. T.L. Turnbull: None. M.T. Rasmussen: None. R.F. LaPrade: 1; Arthrex. 3B; Arthrex, Smith & Nephew. C.A. Wijdicks: 5; Acumed, AlloSource, Arthrex, Biomet, Ceterix Orthopaedics, ConMed Linvatec, DePuy Synthes, OREF, Ossur, Smith & Nephew,...