In an attempt to study the biological activities of flavonoids, a flavone, flavanone and series of chalcones were synthesized and characterized by IR and 1 H NMR and elemental analysis. All the targeted compounds were screened for their antibacterial activity against Bacillus cereus, Enterococcus faecalis, Kleibsiella pneumonia and Pseudomonas aeroginosa and antifungal activity against Aspergil...

The mutagenicity of ten flavonoids was assayed by the Ames test, in Salmonella typhimurium strains TA98, TA100 and TA102, with the aim of establishing hydroxylation pattern-mutagenicity relationship profiles. The compounds assessed were: quercetin, kaempferol, luteolin, fisetin, chrysin, galangin, flavone, 3-hydroxyflavone, 5-hydroxyflavone and 7-hydroxyflavone. In the Ames assay, quer...

Achillea tenuifolia Lam. (Asteraceae) afforded a dichloromethane fraction from which three known compounds β-sitosterol (compound1), 5-hydroxy, 4',6,7– trimethoxy flavone (salvigenin compound 2), and methyl-gallate (compound 3) were isolated for the first time. The structure of isolated compounds was elucidated by different spectroscopic methods. Applying the molar-ratio method, the complexat...

Achillea tenuifolia Lam. (Asteraceae) afforded a dichloromethane fraction from which three known compounds β-sitosterol (compound1), 5-hydroxy, 4',6,7– trimethoxy flavone (salvigenin compound 2), and methyl-gallate (compound 3) were isolated for the first time. The structure of isolated compounds was elucidated by different spectroscopic methods. Applying the molar-ratio method, the complexat...

Achillea tenuifolia Lam. (Asteraceae) afforded a methanolic extract from which after fractionation in solvents with different polarities, two known flavones 3', 5- dihydroxy- 4', 6, 7- trimethoxy flavone (eupatorine, compound 3), 5- hydroxy- 3',4', 6, 7- tetramethoxyflavone (compound 4), besides stearic acid (compound 1), lupeol (compound 2), daucosterol (β- sitosterol 3-O- β- D- glucopyranosid...

6, 8–trimethoxy Flavone and 3, 5–dihydroxy-6, 7, 8–trimethoxy Flavone Concentrations in Rat Colon Tissue C. L. Whitted, V. E. Palau, R. D. Torrenegra, O. E. Rodriguez, S. Harirforoosh East Tennessee State University, Universidad de Ciencias Aplicadas y Ambientales, Universidad del Bosque Purpose In vitro antineoplastic activity against colon cancer cell lines has been previously shown [1]for is...

The methanolic extracts from branches (BEP) and leaves (LEP) of Eysenhardtia platycarpa significantly decreased the blood glucose levels in normal and streptozotocin (STZ)-induced diabetic rats. One new flavone, (1"R)-5,4',1"-trihydroxy-6,7-(3",3"-dimethylchroman)flavone (1), together with the known compounds 5,7-dihydroxy-6-methyl-8-prenylflavanone (3), 5,7-dihydroxy-8-methyl-6-prenylflavanone...

Growth inhibition of the pathogen Staphylococcus aureus with currently available antibiotics is problematic in part due to bacterial biofilm protection. Although recently characterized natural products, including 3′,4′,5-trihydroxy-6,7-dimethoxyflavone [1], 3′,4′,5,6,7-pentahydroxy-flavone [2], and 5-hydroxy-4′,7-dimethoxy-flavone [3], exhibit both antibiotic and biofilm inhibitory activities, ...

The present work deals with the chemometric modeling of antioxidant molecules belonging to the class of flavone derivatives employing the quantitative structure-activity relationship (QSAR) technique. A QSAR model was initially built based on the Fujita-Ban method with the training set molecules. Due to the inability of the Fujita-Ban type model to predict satisfactorily the activity of the tes...

The title compound, C(20)H(16)O(5), {systematic name: 5-hydr-oxy-7-(4-hydroxy-phen-yl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one}, was obtained by demethyl-ation of the biologically active related compound, 4-O-methyl-alpinum-iso-flavone. The mol-ecular structure of the title compound is characterized by a fused tricyclic system that contains an approximately planar benzopyrone ring f...