Mohsen Shahlaei

[ 1 ] - Combined Unfolded Principal Component Analysis and Artificial Neural Network for Determination of Ibuprofen in Human Serum by Three-Dimensional Excitation–Emission Matrix Fluorescence Spectroscopy

This study describes a simple and rapid approach of monitoring ibuprofen (IBP). Unfolded principal component analysis-artificial neural network (UPCA-ANN) and excitation-emission spectra resulted from spectrofluorimetry method were combined to develop new model in the determination of IBF in human serum samples. Fluorescence landscapes with excitation wavelengths from 235 to 265 nm and emission...

[ 2 ] - Phytochemical Analysis and Metal-chelation Activity of Achillea tenuifolia Lam.

Achillea tenuifolia Lam. (Asteraceae) afforded a dichloromethane fraction from which three known compounds β-sitosterol (compound1), 5-hydroxy, 4',6,7– trimethoxy flavone (salvigenin compound 2), and methyl-gallate (compound 3) were isolated for the first time. The structure of isolated compounds was elucidated by different spectroscopic methods. Applying the molar-ratio method, the complexat...

[ 3 ] - Combined Unfolded Principal Component Analysis and Artificial Neural Network for Determination of Ibuprofen in Human Serum by Three-Dimensional Excitation–Emission Matrix Fluorescence Spectroscopy

This study describes a simple and rapid approach of monitoring ibuprofen (IBP). Unfolded principal component analysis-artificial neural network (UPCA-ANN) and excitation-emission spectra resulted from spectrofluorimetry method were combined to develop new model in the determination of IBF in human serum samples. Fluorescence landscapes with excitation wavelengths from 235 to 265 nm and emission...

[ 4 ] - Phytochemical Analysis and Metal-chelation Activity of Achillea tenuifolia Lam.

Achillea tenuifolia Lam. (Asteraceae) afforded a dichloromethane fraction from which three known compounds β-sitosterol (compound1), 5-hydroxy, 4',6,7– trimethoxy flavone (salvigenin compound 2), and methyl-gallate (compound 3) were isolated for the first time. The structure of isolated compounds was elucidated by different spectroscopic methods. Applying the molar-ratio method, the complexat...

[ 5 ] - Discovery of Novel Glucagon Receptor Antagonists Using Combined Pharmacophore Modeling and Docking

Glucagon and the glucagon receptor are most important molecules control over blood glucose concentrations. These two molecules are very important to studies of type 2 diabetic patients. In literature, several classes of small molecule antagonists of the human glucagon receptor have been reported. Glucagon receptor antagonist could decrease hepatic glucose output and improve glucose control in d...

[ 6 ] - Discovery of Novel Glucagon Receptor Antagonists Using Combined Pharmacophore Modeling and Docking

Glucagon and the glucagon receptor are most important molecules control over blood glucose concentrations. These two molecules are very important to studies of type 2 diabetic patients. In literature, several classes of small molecule antagonists of the human glucagon receptor have been reported. Glucagon receptor antagonist could decrease hepatic glucose output and improve glucose control in d...

[ 7 ] - شناسایی پروتئین‌های کلیدی درگیر در بروز سرطان معده به روش In silico

Background: Gastric cancer is the first most common cancer death in Iran. There have been many efforts in finding the most effective proteins in this cancer. Using the proteins identified in gastric cancer combined with advanced computational tools in analyzing biological networks, we have developed a rational method in order to identify candidate proteins associated with this cancer. Materi...

[ 8 ] - Hydrophilic Natural Polymers for Sustained-controlled Release of Calcium Hydroxide

Calcium Hydroxide (CH) is commonly employed as intracanal medicament in endodontics. In order to maximize its therapeutic effects, it is essential to develop new approaches for preparing the controlled drug release systems which, in turn, facilities the dissociation of CH into calcium and hydroxyl ions. This work studies the sustained-controlled release of calcium ions and the effect of pH chan...

[ 9 ] - Hydrophilic Natural Polymers for Sustained-controlled Release of Calcium Hydroxide

Calcium Hydroxide (CH) is commonly employed as intracanal medicament in endodontics. In order to maximize its therapeutic effects, it is essential to develop new approaches for preparing the controlled drug release systems which, in turn, facilities the dissociation of CH into calcium and hydroxyl ions. This work studies the sustained-controlled release of calcium ions and the effect of pH chan...

[ 10 ] - Preparation and characterization magnetic polypyrrole composite microspheres decorated with copper(II) as a sensing platform for electrochemical detection of Carbamazepine

With a facile solvothermal technique, Ssynthesis and application of Fe3O4@PPy–CuIIcomposite microspheres in the carbon ionic liquid matrix have been reported as highly sensitive sensors for voltammetric determination of Carbamazepine (CBZ). The morphology, crystal phase and structure of synthesized The nanocomposite structure was confirmed by routine methods such as transmission electron micros...

[ 11 ] - Preparation and characterization magnetic polypyrrole composite microspheres decorated with copper(II) as a sensing platform for electrochemical detection of Carbamazepine

With a facile solvothermal technique, Ssynthesis and application of Fe3O4@PPy–CuIIcomposite microspheres in the carbon ionic liquid matrix have been reported as highly sensitive sensors for voltammetric determination of Carbamazepine (CBZ). The morphology, crystal phase and structure of synthesized The nanocomposite structure was confirmed by routine methods such as transmission electron micros...