We analyze the structural design and the dynamical properties of a protein kinase network derived from the Transpath database. We consider structural properties, such as feedback cycles, pathway lengths, fraction of shortest pathways and crosstalk. Dynamic characteristics of the network are analyzed by using nonlinear differential equations with a special focus on kinase amplitudes and signal p...

conclusions serum p and ipth levels were independently associated with et-1 and those may play a role in development of endothelial dysfunction in chronic kidney disease. patients and methods in this cross-sectional study, 46 chronic stable hd patients were selected from nephrology departments of tabriz university of medical sciences affiliated hospitals and classified based on phosphorus (p), ...

Past cross-cultural research studies in regulatory focus have showed that East Asians in general tend to be prevention-focused whereas Westerners tend to be promotion-focused. Three studies extend these findings by investigating the role of regulatory focus on people’s experiences in enemyship – how people deal with their personal enemies. Study 1 demonstrated that Hong Kong Chinese, as one of ...

1. Proteolysis of immunoglobulin G with long-acting thyroid-stimulating activity with papain and pepsin shortened the duration of thyroid stimulation in mice prepared for the McKenzie (1958) bioassay. The time-course appeared to be related to molecular size. 2. The activity after proteolysis was recovered solely in the electrophoretically slow F(ab)-fragment. 3. There was no immunological cross...

Spiders produce a variety of silks, and the cloning of genes for silk fibroins reveals a clear link between protein sequence and structure-property relationships. The fibroins produced in the spider's major ampullate (MA) gland, which forms the dragline and web frame, contain multiple repeats of motifs that include an 8-10 residue long poly-alanine block and a 24-35 residue long glycine-rich bl...

Here we introduce the 'interaction generality' measure, a new method for computationally assessing the reliability of protein-protein interactions obtained in biological experiments. This measure is basically the number of proteins involved in a given interaction and also adopts the idea that interactions observed in a complicated interaction network are likely to be true positives. Using a gro...