The present author and coworkers have engaged in the research developments of inorganic phosphate materials with high performance, utilizing characteristic properties phosphates forms crystals glasses. review described our previous regarding (i) preparation fibrous octacalcium (Ca8H2(PO4)6∙5H2O) hydroxyapatite (Ca10(PO4)6(OH)2; HAp) particles due to anisotropic crystal growth, (ii) superplastic...

Delory & King (1943) published a comparative study of the hydrolysis by faecal alkaline phosphatase of a series of phosphoric esters and established a correlation between the pK values of their second phosphate dissociations, the optimum pH for the enzymic hydrolysis and the Michaelis constants of the esters. They showed that the more acid this phosphate dissociation, the more alkaline was the ...

Osteomalacia is a metabolic bone disease in a mature individual, caused by lack of vitamin D or its active metabolites, on account of a number of factors. Osteomalacia is common in females and in countries with less sun shine. It typically presents with body aches, weakness, alongwith signs of bone tenderness and proximal myopathy. Diagnosis is made on the basis of clinical presentation and inv...

Bioactive composites that enable the formation of calcium phosphates have received increased attention over the last decade, in the development of osteoconductive biomaterials for orthopaedic applications. In this work, tripolyphosphate (TPP)-cross-linked chitosan/gelatin composites (TPP-CG) were prepared for the growth of shape- and size-controlled calcium phosphates on/in the composites. The ...

Bone substitutes are nowadays largely used in orthopedic surgery but they lack osteoinductive properties. Poly (2-hydroxyethyl methacrylate) (pHEMA) has numerous biomedical applications. Alkaline phosphatase (AlkP), an ectoenzyme elaborated by osteoblasts, initiates bone mineralization by hydrolyzing organic phosphates before calcium-phosphorus deposition. We have immobilized AlkP in pHEMA in a...