Lifestyle factors such as smoking have been shown to influence urinary mutagenicity. Therefore, these factors have to be considered carefully when evaluating occupational genotoxic exposures. We investigated day-to-day variability in active and passive tobacco smoke exposure by studying urinary cotinine levels and determined their influence on observed urinary mutagenicity. Urinary cotinine was...

One of the most important and serious ecological problems is mutagenic pollution of the natural environment. Therefore, detection of mutagenic compounds in samples taken from natural habitats is of special interest. Microbiological mutagenicity tests seem to be very useful tools for such detection. In this review article, a general view on the tests employing genetically modified bacterial stra...

background the increasing use of herbal drugs and their easy availability have necessitated the use of mutagenicity tests to analyze their toxicity and safety. objectives the aim of this study was to determine the in vitro mutagenicity of artemisia draconculus l., a herbal drug, by performing single cell gel electrophoresis (scge). materials and methods in this study, we obtained a herbal drug ...

Although the use of medicinal plants or natural products has increased in recent decades all over the world, little information is available on their potential risk to health. Annona crassiflora Mart., a plant commonly known as araticum in Brazil, has been widely used in folk medicine for a long time since its seeds and leaves are often utilised in the treatment of cancer, snake bites, and vene...

The conclusions stated after evaluation of 49 test results are presented in Table 1 for the in vivo mutagenicity and in Table 2 for in vitro mutagenicity. To evaluate the mutagenicity of the product, the criteria in point 4.2.2 of the Annex VI to the Directive 67/548/EEC are used. The tests using intra-peritoneal administration are not taken into account to determine the mutagenicity of hydroqu...

Phenyl glycidyl ether and 6 para-subst i tuted derivatives, the methoxy, tert-butyl, methyl, chloro, bromo and nitro compounds, were tested in the Ames' test for mutagenicity. With the exception of the tert-butyl derivative in TA1535, all 7 compounds were mutagenic in both strains TA100 and TA1535. Electron-donating groups in the para position decreased mutagenicity while electron-withdrawing g...

We investigated urinary mutagenicity and colorectal adenoma risk in a clinic-based, case-control study of currently nonsmoking cases (n 143) and controls (n 156). Urinary organics were extracted by C18/methanol from 12-h overnight urine samples, and mutagenicity was determined in Salmonella YG1024 S9 (Ames test). Adenoma risk was 2.4-fold higher in subjects in the highest versus the lowest quin...

A recent report (Calabrese et al., Mutat. Res. 726 (2011) 91-97) concluded that an analysis of Ames test mutagenicity data provides evidence of hormesis in mutagenicity dose-response relationships. An examination of the data used in this study and the conclusions regarding hormesis reveal a number of concerns regarding the analyses and possible misinterpretations of the Salmonella data. The cla...