Implant-associated infection is becoming more and more challenging to the healthcare industry worldwide due to increasing antibiotic resistance, transmission of antibiotic resistant bacteria between animals and humans, and the high cost of treating infections. In this study, we disclose a new strategy that may be effective in preventing implant-associated infection based on the potential antimi...

The increasing rate of antibiotic resistance and slowing discovery of novel antibiotic treatments presents a growing threat to public health. In the present study we develop a Markov Chain model of evolution in asexually reproducing populations which we use to illustrate that different selection pressures do not commute. We demonstrate that the emergence of resistant individuals can be both hin...

Paldimycin (antibiotic 273ai) and antibiotic 273a2 as well as their individual components, paldimycins A (273aia) and B (273ai)s) and antibiotics 273a2a and 273a2^ were synthesized from paulomycin, paulomycin A and paulomycin B, respectively, by reacting with 7V-acetyl-Lcysteine. The semisynthetic antibiotics had chromatographic behavior (TLC, HPLC)and physical and chemical properties identical...

Antibiotic cement has been recommended in the treatment of prosthetic infections. The purpose of this study was to investigate the mechanical behavioral changes in cement loaded with two antibiotics, vancomycin and cefazolin, in dry and liquid medium. Six groups and four study conditions were established according to the doses of antibiotic used and the ageing (immersion in phosphate buffered s...

A summary of recent investigations of the duocarmycins is provided including the total synthesis of (+)-and ent-(-)-duocarmycin SA, the preparation and evaluation of the minimum potent pharmacophore of the alkylation subunit constituting the common pharmacophore of duocarmycin A and SA, the definition and characterization of the DNA alkylation properties of the agents and their correlation with...

The properties of 23 cell-detaching Escherichia coli strains that were isolated from stool specimens in Nigeria are described. Common properties of the strains included the presence of genes encoding alpha-hemolysin (100%), pyelonephritis-associated pili (100%), and cytotoxic necrotizing factor 1 (70%) as well as lactose negativity (70%) and multiple antibiotic resistance (74%). Antibiotic resi...

Nystatin interaction with liposomes mimicking fungal and mammalian membranes (ergosterol- and cholesterol-containing 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) large unilamellar vesicles, respectively) was studied by fluorescence spectroscopy. The activity of this antibiotic was also measured using a pyranine fluorescence detected K+/H+ exchange assay. Nystatin mean fluorescence li...

Background and Objective: Salmonella typhi infection occurs in most endemic areas. Patients suspected of typhoid fever located in the Badda and Shantinagar localities of Dhaka were the studied population. A total of 107 blood specimens were collected. This study attempted to determine the antibiotic susceptibility pattern of Salmonella typhi among different age and gender groups having clinica...