Previously, we showed that the crude methanol extracts of Leucas indica flowers exhibited antioxidant properties and in current study, flower L. anticancerous as evidenced cytotoxicity (MTT assay test) against selected cancerous cell lines HeLa, HCT116, HL-60, MCF-7. Therefore, further analysis was performed to isolate purify bioactive compound using activity-guided repeated fractionation extra...

Tumor hypoxia is causally related with resistance to adriamycin (ADR), and hyperbaric oxygen therapy has been shown to enhance the chemotherapeutic effect of the drug. It is believed that exposure to oxygen leads to an increase of intracellular reactive oxygen species (ROS) concentration. To monitor ROS involvement in this improved anticancerous effect, we used a new method of ROS detection bas...

OBJECTIVES There have been developed to use targeting ability for antimicrobial, anticancerous, gene therapy and cosmetics through analysis of various membrane proteins isolated from cell organelles. METHODS It was examined about the lysosomal membrane protein extracted from lysosome isolated from HeLa cell treated by 100 ppm melanin for 24 hours in order to find associated with targeting abi...

Nanoparticles (NPs) of noble metals, namely gold and silver, remain promising anticancer agents capable of enhancing current surgery- and chemotherapeutic-based approaches in cancer treatment. Bimetallic AgAu composition can be used as a more effective agent due to the synergetic effect. Among the physicochemical parameters affecting gold and silver nanoparticle biological activity, a primary c...

Over expression of Protein kinase (CK2) suppresses apoptosis induced by a variety of agents, whereas down-regulation of CK2 sensitizes cells to induction of apoptosis. In this study, we have built quantitative structure activity relationship (QSAR) models, which were trained and tested on experimentally verified 38 enzyme׳s inhibitors having inhibitory value IC50 in µM. These inhibitors were do...

Parthenin (a sesquiterpene lactone) is a major constituent of parthenium hysterophorus –a noxious weed known for its environmental and health hazardous properties. . It is responsible for imparting the several properties to this weed such as allelpathy, autotoxicity and allergencity. Further, anticancerous, antiameobic and antimalarial properties of the weed are also credited to parthenin. The ...