A full-length cDNA encoding a novel human protein was cloned from placenta cDNA. The corresponding 1542 amino acid protein sequence was termed 'pregnancy-associated plasma protein-E' (PAPP-E) as it shows a 62% homology to the human pregnancy-associated plasma protein-A (PAPP-A) that is a diagnostic marker for trisomies, especially Down syndrome. The conserved domain structure contains five moti...

Metabolic syndrome (MetS) as a collection of obesity-associated disorders is associated with inflammation, oxidative stress, pro-thrombotic state, elevated risk of developing cardiovascular disease and type 2 diabetes. Adiponectin is one of the most abundant peptide hormones derived from adipose tissue. This protein plays a major role in glucose and lipid metabolism and prevents development of ...

background beta-2 microglobulin (b2m) is considered as a surrogate marker for middle molecule uremic toxins and a key component in dialysis-related amyloidosis. however, few studies have evaluated role of b2m in patients with chronic kidney disease (ckd). objectives the purpose of this study was to evaluate the association of plasma b2m level with some metabolic and cardiac performance factors ...

conclusions: these findings suggested that plasma adpn level is inversely associated with gfr and directly correlate with hdl-cholesterol and inversely with some, but not all metabolic factors of ckd patients who were not undergone dialysis. results: plasma adpn level was significantly higher in ckd patients than control group (p = 0.04). it was directly correlated with hdl-cholesterol (r = 0.5...

Background: Metabolic syndrome (MetS) is characterized by a combination of cardio-metabolic risk factors. Given that genetic factors have been shown to contribute to individual susceptibility to MetS, the identification of genetic markers for disease risk is essential. Recent studies revealed that rs780094 and rs1260326 of glucokinase regulatory gene (GCKR) are associated with serum triglycerid...

Background: There are varieties of purification techniques for separation of human plasma proteins such as salting out, ion exchange chromatography, and ethanol fractionation. There are limitations for each method, for example in salting out method, the salt has to be removed in an additional step. Ion exchange chromatography is difficult for scaling up, and plasma fractionation is a time consu...