Studies were conducted to characterize the absorption, disposition, metabolism, and excretion of 1,2-dibromo-2,4-dicyanobutane (BCB; methyldibromoglutaronitrile) following iv, oral, and topical administration to male Fischer 344 rats. Following iv administration of [14C]BCB (8 mg/kg, 120 microCi/kg), no parent compound was detected in the blood; however, its debrominated metabolite, 2-methylene...

The blood-brain barrier, the blood-cerebrospinal fluid barrier (BCB) and other specialized brain barriers are increasingly recognized as a major obstacle to the treatment of most brain disorders. The impairment of these barriers has been implicated in neuropathology of several diseases, such as autism, ischemia, multiple sclerosis and Alzheimer disease. This dual function of the blood-neural ba...

Background: This study was conducted in order to determine whether BCB staining performed on immature bovine oocytes to assess G6pdhlevel has an impact on ivf/ivp technology in bovine embryos. Both spermatozoa and oocytes metabolize glucose through the pentose phosphate pathway (PPP), and NADPH appears necessary for gamete fusion. Activity of glucose 6-phosphate dehydrogenase (G6PDH), the key e...

An algorithm was developed and implemented to find controllers from the stock shares for some financial institutions for the Brazilian Central Bank (BCB). The original problem is similar to a typical Sum of Subset problem that is suggested to be solved by a backtracking algorithm and the problem complexity is NP-complete. Usually BCB solves this problem manually which is time consuming and pron...

Interconversion of carbon sites in boat-chair-boat (BCB) cyclodecane occurs by way of the twist-boat-chair (TBC) conformation, which predicts that C-1 exchanges with C-4, etc. The previously obtained low-temperature 13C spectra could be matched by assuming (1,4) or (1,3) exchange, but not (1,2) exchange. A free-energy barrier of 5.54 kcal/mol was obtained for conversion of BCB to TBC at -137.4 ...

Abstract Using the critique of instrumental rationality, based on Weber, Habermas and Arendt, we analyze, through interviews leaders involved in creation Central Bank Brazil (BCB), tension between politics technique its formation as a bureaucracy. This oral history research was conducted by CPDOC/FGV, published 2019, 25 volumes "Told History Collection," with who participated BCB. As result, id...

This paper is the next installment in a series (Sobieszczanski-Sobieski et al. 1998, Kincaid et al. 2000, 2001, 2002 and Plassman and Sobieszczanski-Sobieski 2000) that has introduced a variant of the Genetic Algorithm in which the reproduction mechanism was modified to base it on the Gaussian probability distribution, the bell curve. The bell-curve based (BCB) heuristic procedure, first presen...

Background: Cryopreservation of farm animal embryos is nowadays a widely used routine technique. Success in cryopreservation of form animal depends on many factors including: freezing medium, types of cryoproctants, melting process, lipid content in ooplasm and oocyte quality It has been found that immature Oocytes with reduced reproductive performance or slaughtered at the end of their use are...