INTRODUCTION Povidone-iodine aqueous solution is an antiseptic commonly used in ophthalmology for treatment of the ocular surface. Dimethylsulfoxide (DMSO) is a well-known skin penetration enhancer that is scarcely utilized in ophthalmic drug formulations. We describe here a low-dose formulation of 0.25% PVP-I in a gel containing DMSO for the treatment of Demodex blepharitis. CASE REPORT A 95...

BACKGROUND Blepharitis is an ocular surface disease and chronic ophthalmic condition. This paper reports on the development of psychometric evaluation of a patient-reported measure of blepharitis symptoms. METHODS Self-reports of 13 blepharitis symptoms collected in a Phase 3 multi-site, randomized, double-masked, 4-arm parallel group, clinical trial of 907 individuals with blepharitis (mean ...

purpose: to investigate tear function in acne vulgaris patients who were treated with isotretinoin (accutane). methods: in this prospective clinical study, patients who were scheduled for isotretinoin (accutane) therapy for two months underwent complete eye examination.the best corrected visual acuity measurement, careful slit lamp examination of anterior segment, evaluation of break-up-time an...

PURPOSE To evaluate the tolerability on healthy volunteers and the efficacy on subjects affected by chronic moderate/severe blepharitis of a 5% glycyrrhizin and copolymer poly(ethylene glycol)/poly(propylene glycol)(PEG/PPG) ophthalmic solution. METHODS The study was a randomized, controlled, open label, intra-patient monocentric study. It consisted of two different phases, the assessment of ...