Background: Spermatogenesis is under the control of variety of factors, which include mast cells. Any changes in testicular mast cells’ number and distribution resulting in deterioration of comlex regulation and fine-turning of spermatogenesis. Increased number of mast cells and their abnormal spread pattern have been described in the testis with fertility disturbances. Mast cells’ tryptase enz...

introduction: morphology and ultra-structure of myoid and sertoli cells were studied in patients with non-obstructive azoospermia who were admitted to testicular sperm extraction (tese) and intracytoplasmic sperm injection (icsi), by transmission electron microscopy (tem). materials and methods: 12 biopsies of testicular tissues from patients with non-obstructive azoospermia referred to royan i...

abstract diabetes mellitus (dm) is one of the greatest public health threats in modern societies. although during a few years it was suggested that dm had no significant effect in male reproductive function, this view has been challenged in recent years. from a clinical perspective, the evaluation of semen parameters, as well as spermatozoa deoxyribonucleic acid (dna) integrity, are often studi...

background & aims of the study: oxidative stress increases platelet-derived growth factor (pdgf) gene expression in endothelial cells that contributes to vascular dysfunction and atherosclerosis. oxidative stress generates by dys-regulated redox balance between ros producing systems and antioxidant systems. also, curcumin (cur) as a main part of turmeric has anti- inflammatory, antioxidant, ant...

poultry spermatogonial stem cells (sscs) have the potential to serve as a model for studying the basic biology of ssc and they can also be used for biotechnological purposes. however, the small number of sscs and the presence of the testicular somatic cells with sscs have limited their applications. therefore, this study was undertaken for the first time to investigate the effect of a serum-fre...

The respiratory tract contains numerous peptides secreted from special pulmonary epithelial cells whichare called endocrine cells. The function of neuroendocrine cells is modulated by amines. Serotonin has strong vasomotor and bronchomotor effects in the airway mucosa. The objective of this study was to determine presence and distribution of serotonin-positive endocrine cells in respiratory tra...

The objective of this study was to evaluate the effects of two different levels of food restriction on testicular angiogenic activity, microvascularization, tissue growth, and regression, using the rabbit as a study model. The rabbits (Oryctolagus cuniculus cuniculus) were randomly assigned to a control group (A, n=5), fed ad libitum, and to groups B (n=5) and C (n=5), with two different levels...

the respiratory tract contains numerous peptides secreted from special pulmonary epithelial cells whichare called endocrine cells. the function of neuroendocrine cells is modulated by amines. serotonin has strong vasomotor and bronchomotor effects in the airway mucosa. the objective of this study was to determine presence and distribution of serotonin-positive endocrine cells in respiratory tra...

Non-primate mammals have two deleted azoospermia (DAZ) family genes, DAZL and Boule; genes in this family encode RNA-binding proteins essential for male fertility in diverse animals. Testicular DAZL transcription is regulated by epigenetic factors such as DNA methylation. However, nothing is known about the epigenetic regulation of Boule. Here, we explored the role of DNA methylation in the reg...