Objective(s): A growing body of evidence indicates that rhomboid domain containing 1 (RHBDD1) plays an important role in a variety of physiological and pathological processes, including tumorigenesis. We aimed to determine the function of RHBDD1 in breast cancer cells. Materials and Methods: In this study, we used the Oncomine™ database to determine the expression patterns of RHBDD1 in normal a...

background: the aim of this study was to detect prognostic factors in recurrent breast cancer metastasis. materials and methods: th is retrospective cohort study employed data from 996 breast cancer patients of isfahan seyed-o-shohada research center from 1998 to 2010. stratifi ed cox proportional hazards model, marginal approach, was used to evaluate the prognostic value of estrogen receptor, ...

background: chemokine receptors have been shown to play an important role in the development and metastatic spread of various malignancies. in this study, the gene expression profile of some key chemokine receptors involved in metastasis has been investigated in esophageal and breast cancer cell lines.   methods: in a descriptive study, gene expression profile of ccr1, ccr6, ccr7, ccr9, cxcr1, ...

objective(s):breast cancer is an important leading cause of death from cancer. stathmin and tau proteins are regulators of cell motility, and their overexpression is associated with the progression and bad prognosis of breast cancer. memantine, an n-methyl-d-aspartate (nmda) receptor antagonist, is the potential inhibitor of tau protein in neurons. this study determines the effect of memantine ...

Objective(s): The growing trend of research demonstrates that dynamic expression of two metastasis repressor classes (metastasis suppressor genes and anti-metastatic miRNA) has a close relationship with tumor invasion and metastasis. Using different strategies, it was revealed that cellular levels of miR-31 and Breast cancer Metastasis Suppressor1 (BRMS1) protein, whic...

Breast cancer is one of the most common malignancies among women and considered as the first caise of mortality in females suffering from malignant processes.axillary lymph node metastasis (ALNM)is the most important predictor of survival in patient with breast carcinoma.the purpose of this study was to determine the association between the incidence of ALNM and morphologic criteria by univaria...

objective(s): berberine is one of the main alkaloids and it has been proven to have different pharmacological effects including inhibition of cell cycle and progression of apoptosis in various cancerous cells; however, its effects on cancer metastasis are not well known. cancer cells obtain the ability to change their chemokine system and convert into metastatic cells. in this study, we examine...