Random-bred Swiss mice were bred selectively for their agglutinin responses to sheep and pigeon erythrocytes to obtain high and low responder lines for those antigens (1). After 20 generations, the two lines differed markedly in their mean agglutinin titers against sheep erythrocytes and were considered established, since the difference in agglutinin response could not be increased by further b...

Honey bee (Apis mellifera L.) colonies bred for hygienic behavior were tested in a large field trial to determine if they were able to resist the parasitic mite Varroa destructor better than unselected colonies of"Starline" stock. Colonies bred for hygienic behavior are able to detect, uncap, and remove experimentally infested brood from the nest, although the extent to which the behavior actua...

Mice selectively bred for high wheel-running activity (S) have decreased fat content compared to mice from randomly bred control (C) lines. We explored whether this difference was associated with alterations in levels of circulating hormones involved in regulation of food intake and energy balance, and whether alterations were caused by the presence of a running wheel. Plasma levels of leptin, ...

Cassava roots undergo postharvest physiological deterioration (PPD), and for most varieties it sets in within 72 hours of harvest. An untargeted metabolomics approach combined with a data-driven statistical analysis was used to characterize profile high beta-carotene cassava the aim identifying any relevant metabolite changes that occur during PPD. Sixteen root samples from four lines were plan...

Honey bee (Apis mellifera L.) colonies bred for hygienic behavior were tested in a large Þeld trial to determine if they were able to resist the parasitic mite Varroa destructor better than unselected colonies of “Starline” stock. Colonies bred for hygienic behavior are able to detect, uncap, and remove experimentally infested brood from the nest, although the extent to which the behavior actua...

The goal of the study was to measure spontaneous and amphetamine-induced motor and locomotor activity in three selectively bred lines of male Long-Evans rats. The number of 50 kHz ultrasonic vocalizations (USVs) emitted in response to heterospecific play with human hand ("tickling") had been measured daily in these lines of rats from 21 to 24 days of age, as a criterion for dividing them into h...

The endocannabinoid system (ECS) is involved in regulation of various physiological functions, including locomotion, antinociception, emotional states, and motivated behaviors. The ECS has been implicated in regulation of voluntary wheel running in mice via actions at the cannabinoid receptor-1 (CB1). Previously, we showed that four replicate lines of mice bred for high levels of voluntary whee...

We studied expression of heat shock protein 72 (HSP72) in female mice from four replicate lines that had been selectively bred for high voluntary wheel running (S) and from four random-bred control lines (C). Mice from generation 23 were sampled after 6 days of wheel access, and those from generation 14 were sampled after 8 wk of access to wheels either free to rotate or locked. Mice from S lin...

Chronic alcohol intake is associated with dramatic disruptions in sleep and other circadian biological rhythms in both humans and experimental animals. In human alcoholics, these disruptions persist during extended abstinence and appear to promote relapse to drinking. Whereas chronic ethanol intake alters fundamental properties of the circadian pacemaker in unselected rats, nothing is known con...

The phagocytic index K, established from the rate of blood clearance of colloidal carbon, measures the phagocytic activity of RE macrophages in contact with the circulating blood. The intravenous injection of glyceryl trioleate (triolein) produces a marked stimulation of the phagocytic activity of RE macrophages. This response is higher in the female than in the male mice. The phenotypic charac...