ZAROR-BEHRENS, CLORIA,ANDJEANHIMMS-HAGEN. Coldstimulated sympathetic activity in brown adipose tissue of obese (ob/ob) mice. Am. J. Physiol. 244 (Endocrinol. Metab. 7): E36LE366, 1983.-The objective was to find out whether‘the known failure of brown adipose tissue thermogenesis in the cold-exposed genetically obese (ob/ob) mouse might be due to a defect in the usual cold-induced increase in sym...

The function ascribed to brown adipose tissue in humans has long been confined to thermoregulation in neonates, where this thermogenic capacity was thought lost with maturation. Recently, brown adipose tissue depots have been identified in adult humans. The significant oxidative capacity of brown adipocytes and the ability of their mitochondria to respire independently of ATP production, has le...

A dipose tissue can release a plethora of factors termed adipokines. The large family of adipokines includes chemokines, cytokines, lipid factors, and growth factors. Adiponectin, the first cloned protein hormone from adipose tissue, is a metabolically active and anti-inflammatory adipo-kine. Adiponectin mainly circulates in different oligomeric isoforms, including high molecular weight adipone...

Lipogenesis in brown adipose tissue of virgin rats increased 8--10-fold after intragastric feeding with glucose or medium-chain triacylglycerol, and this increase was prevented by short-term insulin deficiency. Brown adipose tissue increased in weight during pregnancy, regressed during lactation and hypertrophied again on weaning; the rate of lipogenesis paralleled these changes. Glucose did no...

Brown adipocytes are thermogenic cells which play an important role in energy balance. Their thermogenic activity is due to the presence of a mitochondrial uncoupling protein (UCP). Until recently, it was admitted that in rodents brown adipocytes were mainly located in classical brown adipose tissue (BAT). In the present study, we have investigated the presence of UCP protein or mRNA in white a...

Brown adipose tissue is one kind of adipose tissue and regulates body temperature and balance of energy via non-shivering thermogenesis. The authors present a case that strongly suggested the presence of activated brown adipose tissue in the neck, shoulders and axillary space by increased 18F-FDG uptake. 99mTc-sestamibi and 201Tl dual-tracer SPECT study showed increased 99mTc-sestamibi uptake a...

With the finding that brown adipose tissue is present and negatively correlated to obesity in adult man, finding the mechanism(s) of how to activate brown adipose tissue in humans could be important in combating obesity, type 2 diabetes, and their complications. In mice, the main regulator of nonshivering thermogenesis in brown adipose tissue is norepinephrine acting predominantly via β(3)-adre...

An increase in liver: body-weight and in hepatic triacylglycerol content, together with changes in the fatty acid profiles of hepatic phospholipids, were observed as a result of moderate riboflavin deficiency in sucking rat pups. Oxygen consumption by hepatic mitochondria, with palmitoyl L-carnitine as substrate, was not significantly impaired. Mitochondria from interscapular brown adipose tiss...

Note Brown adipose tissue is rich in glycogen, cholesterol and phospholipids. In contrast to white adipose tissue, which stores energy, brown fat is involved in nonshivering thermogenesis. This ability is dependent on the expression of uncoupling protein 1 (UCP1), a mitochondrial proton transporter that uncouples electron transport from ATP production. In humans, brown adipose tissue typically ...