A number of prospective randomized studies have recently been designed to address the question of whether autografting prolongs survival for patients with chronic myelogenous leukemia (CML) in chronic phase,1,2 but there is no general agreement as to the optimal approach to cytoreduction before transfusion of autologous stem cells. We believe that the use of high-dose busulfan alone, as used in...

The aim of the present study was stereological evaluation of testes of azoospermic animal model using busulfan in rat. Three groups of male adult rats were used in this study. The first group was injected by single dose of busulfan (10 mg kg-1) and their testes were removed on day 35 post injection. The second group received double doses of busulfan with 21 days interval and their te...

introduction: busulfan as a chemotherapeutic agent causes testicular germinal epithelium depletion and cytotoxicity in germ cells. the aim of this study was to assess antioxidant status, reactive oxygen species (ros) generation and apoptosis-related genetic markers of adult male mouse sperm following busulfan treatment. materials and methods: forty adult nmri mice (30 ± 5 g) were divided into t...

In bone marrow transplantation, high-dose busulfan is given p.o., usu ally every 6 h over 4 consecutive days. Since this repeated administration might alter busulfan disposition, fluctuations in busulfan plasma levels were studied over the 4-day treatment period in 21 children (median age, 5 years) with malignant solid tumors. In addition, urinary excretion of unchanged busulfan was measured ev...

Busulfan, a sulfonic acid ester, is an alkylating agent with potent toxicity for hematopoietic and sinusoidal endothelial cells. The drug was initially introduced in 1952, as a treatment modality for patients with chronic myeloid leukemia. It was only around 20 years later that this agent was first used as part of the conditioning regimen in bone marrow transplantation, substituting total body ...

Background: Busulfan is a chemotherapy drug that is widely used for cancer treatment. However, administration of busulfan to male patients with malignant diseases may cause temporary or permanent sterility. Therefore, research into drugs or Materials to reduce the side effects of busulfan on the male reproductive system is necessary. In the present study the protective effects of L-carnitine an...

BACKGROUND & OBJECTIVES Busulfan (Bu) in combination with cyclophosphamide is widely used in myeloablative conditioning regimen prior to haematopoietic stem cell transplantation (HSCT). Its narrow therapeutic range and toxic side effects at high systemic exposure and graft rejection at low exposure emphasize the need for busulfan dose optimization using targeted dose adjustment prior to HSCT. W...

Introduction: Aplastic anemia is a disorder characterized by peripheral pancytopenia and hypoplastic bone marrow. Papaya, botanical name Carica tropical fruit with wide range of benefits. In past couple years, researches have been carried out on beneficial outcomes papaya leaf juice blood marrow, particularly platelet count. Aim: Taking into consideration the effects leaves current research was...

BACKGROUND Busulfan(Bus) is a chemotherapy drug that is widely used for cancer treatment. However, administration of busulfan may cause temporary or permanent sterility in male patients. Therefore, reduction of this side is necessary. OBJECTIVE evaluation of the protective effects of L-carnitine and testis homogenized tissue(THT) on sperm parameters and the testis structure after busulfan tre...

The effects of pretransplant conditioning with high-dose busulfan, a myeloablative but nonimmunosuppressive alkylating agent, on reconstitution of lymphoid tissues by donor cells after bone marrow transplantation (BMT) has not been extensively examined. We used flow cytometric analyses to study the kinetics and extent of lymphocyte repopulation in C57BL/6 mice (immunophenotype Ly-5.2) given gra...