Testicular damage is one of the most hazardous effects chemotherapy as it frequently associated with oligozoospermia and azoospermia. This study aimed at evaluating protective effect melatonin in a rat model busulfan-induced testicular injury. Rats were divided into four groups: control, melatonin, busulfan, busulfan plus melatonin. After 15 days, semen was collected from epididymis testes asse...

Busulfan is an alkylating agent affects ovarian follicles growth by oxidative stress induction. Satureja khuzestanica has antioxidant effects. The aim of this study was to examine whether S. khuzestanica essential oil (SKEO) exhibits protective effects on busulfan-induced ovarian failure. Eighty-four adult female mice were divided into six groups including dimethyl sulfoxide (...

the aim of the present study was stereological evaluation of testes of azoospermic animal model using busulfan in rat. three groups of male adult rats were used in this study. the first group was injected by single dose of busulfan (10 mg kg-1) and their testes were removed on day 35 post injection. the second group received double doses of busulfan with 21 days interval and their testes were r...

Busulfan is known to cause several adverse effects including reproductive toxicity in humans. Garlic (Allium sativum), a widely distributed medicinal plant, is highly regarded for its medicinal activities including antioxidant property.This study was conducted to assess whether garlic extract could serve as protective agents against testicular toxicity during busulfan treatment in a mi...

Kidney diseases endanger human health and place a heavy burden on global care systems. The current study aimed to explore the beneficial advances of alginate oligosaccharides (AOS) as functional food kidney structure function, underlying mechanisms with busulfan disrupted model. We found that AOS improved renal tubules. Busulfan increased protein levels injury marker molecule-1, apoptosis caspa...

BACKGROUND Busulfan is used in preparative regimens prior to stem cell transplantation in pediatric patients. There is significant interpatient variability in busulfan pharmacokinetics (PK) and exposure is related to outcome. To date, only polymorphisms in genes encoding for glutathione-S-transferases were studied, but could only explain a small portion of the variability in PK. AIM To invest...

Osteosarcoma typically arises in tissues of mesenchymal origin, and is the most malignant bone tumor characterized by high local aggressiveness, with poor therapeutic outcome. Busulfan has been widely used to treat CML. So far, there are no reports on the therapeutic effect of busulfan on osteosarcoma. Here, we showed that busulfan dose-dependently reduced the cell viability and proliferation, ...

Background: Chemotherapy or irradiation is associated with impaired fertility. The aim of this study was to investigate the possible protective role of testosterone enanthate (TE) on the proliferative activity, plasma testosterone level and morphometry of epithelial cells of seminal vesicles in busulfan-induced spermiotoxicity. Materials and Methods: Sprague- Dawley rats were divided into 4 gro...

We have examined the catalytic activity of glutathione .S'-transferases (GST) in the conjugation of busulfan with glutathione (GSH) in human liver cytosol. purified human liver GST. and cDNA-expressed GST-al-1. Human liver microsomes and cytosol were incubated with 40 /IM busulfan and 1 m\i (.SII. Cytosol catalyzed the formation of the GSH-husulfan tetrahydrothiophenium ion i III I ' i in a con...