Background: In gene therapy, the use of RNA molecules as therapeutic agents has shown advantages over plasmid DNA, including higher levels of safety. However, transient nature of RNA has been a major obstacle in application of RNA in gene therapy. Methods: Here, we used the internal ribosomal entry site of encephalomyocarditis virus and the 3’ non-translated region of Poliovirus to design an en...

objective: breast cancer is the second leading cause of cancer death in women. cisplatin is a traditional cancer drug commonly used in chemotherapy for killing cancer cells. modulation at the mrna levels of apoptotic related genes often correlate with the sensitivity of various types of cancer cells to chemotherapeutic agents. nanoparticulate drug delivery systems are being developed to effecti...

Gene therapy has been recently proposed as an effective strategy for cancer treatment. A significant body of literature proved the effectiveness nanocarriers to deliver therapeutic agents 2D tumour...

background: chemokine receptors have been shown to play an important role in the development and metastatic spread of various malignancies. in this study, the gene expression profile of some key chemokine receptors involved in metastasis has been investigated in esophageal and breast cancer cell lines.   methods: in a descriptive study, gene expression profile of ccr1, ccr6, ccr7, ccr9, cxcr1, ...

Background: Radiation therapy is among the most conventional cancer therapeutic modalities with effective local tumor control. However, due to the development of radio-resistance, tumor recurrence and metastasis often occur following radiation therapy. In recent years, combination of radiotherapy and gene therapy has been suggested to overcome this problem. The aim of the current study was to e...

Interferon (IFN) therapy has been the standard of care for a variety cancers decades due to pleiotropic actions IFNs against malignancies. However, little is known about role copy number alteration (CNA) IFN gene cluster, located at 9p21.3, in cancer. This large individual patient data meta-analysis using 9937 patients obtained from cBioportal indicates that CNA cluster prevalent among 24 cance...

Tumor heterogeneity and constant selection of therapy-resistant cancer cells in the tumor require combinatorial approaches to treatment that affect various vital processes tumor. Immunotherapy made a revolution among treatment. Today, many methods are grouped around this type Most antitumor immunotherapeutic agents administered intravenously, which cause serious, often life-threatening, side ef...

today, use of nanotechnology for cancer therapy is an active field of research. early detection, accurate diagnosis, and individual treatment are the aims which cause nanotechnology as an attractive area for research. among metallic nanomaterials, gold nanostructures have unique properties which make them remarkable candidates for biomedical approaches. surface plasmonic resonance (spr) effect ...