Pyroptosis is a type of acute cell death that mainly occurs in immune cells. It characterized with robust release inflammatory cytokines and has emerged to play critical role the pathogenesis sepsis-associated disorders. In this study, we screened for pyroptotic inhibitors ultimate goal benefit sepsis treatments. Accidentally, identified nitrosonisoldipine (NTS), photodegradation product calciu...

To investigate the effect and related mechanism of propofol anesthesia on pyroptosis in neonatal rat hippocampus. Neonatal rats were divided into a control group (injected intraperitoneally with saline), 80 mg/kg propofol) propofol+MCC950 10 MCC950) administered for 5 d. The day after end drug administration, hippocampi analyzed by transferase dUTP nick labeling assay interleukin beta-1, interl...