background apoptosis is a physiological mechanism of cell death and it can be triggered by a variety of internal and external stimuli. it has been indicated that some opium derivatives develop cell apoptosis. objectives the aim of this investigation was to evaluate the effect of opium addiction on ovary cell apoptosis in diabetic and non-diabetic wistar rats. materials and methods this experime...

background: breast cancer is the most common diagnosed cancer among women in the world. snail1 plays a role in the development of the invasive phenotypes of cancer, neural cell differentiation, cell division and apoptosis in tumor cells. traces of snail1 in metastasis of breast cancer to bone are observed. the aim of this study was to investigate the effect of specific snail1 sirnas on the prol...

chronic lymphocytic leukemia (cll) remains an incurable disease that requires innovative new approaches to improve therapeutic outcome. many ferula species, including f. asa-foetida, synthesize terpenyloxy coumarins. one of these coumarins is umbelliprenin, which has been implicated with induction of apoptosis in some cancer cell lines.     in this study induction of apoptosis by umbelliprenin ...

apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development and tissue homeostasis. caspases, a family of cysteine-dependent aspartate-directed proteases, play a critical role in the initiation and execution of apoptosis. in this study, cytotoxicity and apoptogenic effect of 2-phenyl 4-carboxamide derivatives were evaluated in sknmc (huma...

Background: Cell viability and apoptosis are two crucial factors that may determine cell fate. There are several factors, such as hypoxia, which may be effective in cell processes. Because of its unique features, such as its antioxidant, anti-inflammatory, and anti-apoptosis mechanisms, kohlrabi (Brassica oleracea var. gongylodes) extract may be used in the amelioration of cell viability and a ...

apoptosis, or active cell death, is a specific mode of cell death, which is characterized by morphological changes such as chromatin condensation, fragmentation of the nucleus, cytoplasmic retraction and appearance of apoptotic bodies' containing apparently intact organelles. apoptosis occurs in physiological conditions as a regulatory mechanism of tissue growth, where cell proliferation is bal...

objective(s): hyperglycemia, oxidative stress and apoptosis have key roles in pathogenesis of diabetic neuropathy. there are local renin-angiotensin systems (rass) in different tissues such as neural tissue. local rass are involved in physiological and pathophysiological processes such as inflammation, proliferation and apoptosis. this study aimed to investigate the role of local renin-angioten...

objective(s): t-cell acute lymphoblastic leukemia (t-all) is an aggressive hematologic malignant tumor. administration of chemical compounds influencing apoptosis and t cell development has been discussed as promising novel therapeutic strategies. valproic acid (vpa) as a recently emerged anti-neoplastic histone deacetylase (hdac) inhibitor and pioglitazone (pgz) as a high-affinity peroxisome p...