Stem cell-based therapy has great potential in treating health conditions including cardiovascular, autoimmune, type I diabetes, neurodegenerative and bone and cartilage diseases also in spinal cord injuries, malformations and cancer. In addition to their potential use to treat systemic diseases, stem cell-based therapy also provides a powerful tool to treat oral and dental diseases such as cra...

Introduction: Radiation-induced bystander effect (RIBE) is a well-known response associated with the induction of radiation effects in non-irradiated cells via signaling of hit ones. As this so-called phenomenon has been largely investigated in low dose levels, few studies focused on higher dose levels such as grid therapy. Grid therapy or spatially fractionated gri...

context connective tissue cells include fibroblasts, chondrocytes, adipocyte, and osteocytes. these cells are specialized for the secretion of collagenous extracellular matrix and are responsible for the architectural framework of the human body. evidence acquisition connective tissue cells play a central role in supporting as well as repairing tissues and organs. fibroblast cell therapy could ...

the first necessary step in researches to treat spinal cord injuries (sci) is to understand complexities related to the neurophysiology and neurobiology changes of human sci with stem cell therapy(sct). the aim of this study is to identify these changes. the level of injuries is important in treatment and determination of this injury (whether it is complete, incomplete, or discomplete) is valua...

it is estimated that annually 10 million people are affected by traumatic brain injury and it is one of the major causes of death and disability in accidents. studies have shown the potential therapeutic value of neural stem cell therapies. also, neural stem cell motility and migration to the site of injury has a great regeneration value of the damaged tissues. extracellular and intracellular f...

epilepsy is neurological disorders that afflict many people around the world with a higher prevalence rate in children and in low income countries. temporal lobe epilepsy (tle) is result from hippocampal sclerosis is a neurological disorder with difficult treatment. stem cells can transform into any type of cells such as glial cells, consequently stem cells can use for medical treatment. stem c...

cell based therapeutics is one of the most rapidly advancing medical fields, bringing together a range of fields including transplantation, tissue engineering and regeneration, biomaterials and stem cell biology. however, traditional cell-based therapeutics have many limitations, one of which is their harmful effects exhibited on healthy body cells due to their lack of specificity. nanomedicine...

this study was conducted to optimize a highly efficient mrna transfection into dendritic cells (dc) derived from esophageal squamous cell carcinoma (escc) patients. applying an electroporation technique, in vitro synthesized green fluorescent protein (gfp) mrna was transfected as an indicator into the dcs derived from a healthy donor. flow cytometry revealed 84.9% transfection efficiency for dc...

objective: sexual dysfunction is frequently reported as a side effect of many antidepressant medications. as a result, for those depressed patients to whom sexual desire is important, psychological treatment may be a better intervention. thus, the present study aimed to determine the possible changes in sexual desire following psychological treatments in depression, when focus of therapy is not...

Cell based therapeutics is one of the most rapidly advancing medical fields, bringing together a range of fields including transplantation, tissue engineering and regeneration, biomaterials and stem cell biology. However, traditional cell-based therapeutics have many limitations, one of which is their harmful effects exhibited on healthy body cells due to their lack of specificity. Nanomedicine...