This paper describes optimization method that combines the Plackett-Burman design, a factorial design and the response surface method, which were used to optimize the medium for the production of L-asparaginase by Serratia marcescens SB08. Four medium factors, from out of 11 medium factors, were screened by Plackett-Burman design experiments and subsequent optimization process to find out the o...

Cutting tests were conducted to medium carbon steel using HSS tools with cutting fluid. The experimental design used was based on response surface methodology (RSM) using a central composite design. Chips were collected at different machining conditions and thickness and microhardness measurements taken and analyzed using “DESIGN EXPERT 7” experimental design software. Mathematical models of th...

abstract: aqueous enzymatic extraction of oil from pistacia khinjuk was performed using cellulase. the central composite design was used to optimize the parameters that are significant to the process. the influence of three regressors on the percentage of oil recovery from seed was evaluated using second-order polynomial multiple regression model. analysis of variance showed a high coefficient ...

a novel, simple, sensitive and effective method has been developed for preconcentration of hg(ii) on nano-fe3o4-dop-ed solid-phase extraction adsorbent. in this paper, dioctyl phthalate (dop) was used to encapsulate nano-fe3o4 and produce a nano-fe3o4-dop sorbent based new sorbent was prepared. this was treated with ethylenediamine (ed) in another solvent-free procedure for the formation of a n...

When mechanically induced progressive failure of rock and the associated changes in hydro fracturing process, it is difficult to track the dynamic evolution of fractures beneath the earth. To overcome this, recent developments in hydro-fracturing technique have tended to follow hybrid approaches. An attempt was made to develop an empirical relationship to predict the Fracture length in millimet...

Electron beam butt welding of stainless steel (SS 304) and electrolytically tough pitched (ETP) copper plates was carried out according to central composite design of experiments. Three input parameters, namely accelerating voltage, beam current and weld speed were considered in the butt welding experiments of dissimilar metals. The weld-bead parameters, such as bead width and depth of penetrat...

The preformulation of insoluble drugs, sulfadiazine and aluminium hydroxyde, were studied in order to achieve a suspension with desirable requirements. The objective of the formulator is to avoid the irreversible aggregation called “caking”, and to obtain a suspension with an airy, large volume sediment easily redispersible and with suitable rheological properties. An experimental design useful...