background & objectives: tumor diathesis (td) is defined as granular proteinaceous precipitates on slide surface of cytologic smears. it is found in the background of smears of invasive carcinoma but not in all cases. the aim of present study was to determine the prevalence of td in cervicovaginal smears from patients with uterine cervix carcinoma. methods: cytological smears and histologi...

The aim of the present study was to determine the preliminary mechanism of action of B7 homolog 1 (B7-H1) and investigate the association between B7-H1 and cervical cancer. The expression of B7 family proteins was measured in cervical cancer cells. Cervical cancer cells were co-cultured with T lymphocytes. An ELISA assay was subsequently conducted to analyze cytokine concentrations in the super...

Cervical cancer as one of the major malignant tumors seriously threatens women's health. More than 270,000 women die cervical each year. Warangalone is an isoflavone compound isolated from Cudrania tricuspidata with excellent antitumor activity. In this research, we investigated molecular mechanism warangalone-induced apoptosis in HeLa cells. The results show that warangalone can selectively an...

cancer is a group of diseases characterized by uncontrolled proliferation of abnormal cells. because of the severe side effects and resistance to the traditional chemotherapeutic agents, the necessity for discovery of new anticancer drugs is a crucial topic. in the present study we synthesized new derivatives of 2-(4-fluorophenyl)- n -halophenylacetamide and assessed their cytotoxicity against ...

Objectives: Ziziphus Jujube (Jujube) plant has exhibited numerous medicinal and pharmacological properties including antioxidant and anti-inflammatory effects. This study was carried out to investigate its anti-cancer and pro-apoptotic abilities in human cervical and breast cancer cells in vitro. Materials and Methods: The cervical OV2008 and breast MCF-7 cancer cells were incubated with differ...

objective: cervical cancer is the second most common cause of death from cancer in women throughout the world. the aim of this study was to evaluate the cytotoxic activity of kelussia odoratissima (k. odoratissima) extract associated with radiotherapy in cervical cancer cells (hela cell line).materials and methods: different concentration of the extract (25-500µg/ml) was tested in hela cell lin...

the aim of this study was to evaluate the defense cells changes of cervical mucous during follicular and luteal phases of estrus cycle in river buffalo. reproductive organs of the adult and apparently healthy female buffaloes were collected from the slaughterhouse. by visual investigation of both the ovaries for presence of corpus luteum and growing follicles, the luteal and follicular phase of...

Background & Aim:Cervical cancer is the most common   female genital cancer and the second most common cancer in women in the   world. Since the herbal ingredients have been used for centuries to treat   cancer, purpose of the present study was to determine the cytotoxic   effect of hydroalcoholic extract from Satureja bachtiarica Bungeon   Hela cancer cells line. ...

objective(s):eukaryotic translation initiation factor 4e (eif4e) is overexpressed in cervical cancer (cc). however, the molecular mechanisms are unclear. this study aimed to investigate the molecular mechanism of eif4e gene overexpression in cc. materials andmethods:the human papillomavirus (hpv) type 18 e7 and eif4e mrnas were measured following knock down or overexpression of e7 gene by rt-pc...