background: recurrent miscarriage is defined as two or more recurrent spontaneous miscarriages. several causes have been suggested, among which, chromosomal abnormalities in couples is considered to have a role in this regard. however, its significance varies among different populations. the present study was carried out to evaluate the prevalence of chromosomal aberrations in couples with recu...

Ring chromosomes are rare chromosomal disorders that usually appear to occur de novo. A ring chromosome forms when due to deletion both ends of chromosome fuse with each other. Depending on the amount of chromosomal deletion, the clinical manifestations may be different. So, ring 18 syndrome is characterized by severe mental growth retardation as well as microcephaly, brain and ocular malformat...

Background: Spontaneous abortion (SAb) is the most common complication of early pregnancy. Numerous risk factors are associated with an increased risk of pregnancy loss such as: Maternally age, previous spontaneous abortion, prolonged ovulation to implantation, Gravidity, Interval Prolonged time to pregnancy, Balanced chromosomal translocations and Genetic disorders. The aim of this study was t...

Background: Most of our current understanding of the biological effects of exposure to ionising radiation is based on conventional cytogenetic techniques, which enable us to determine the relationship between chromosomal aberration and dose received by radiation workers. However, conventional techniques have numerous limitations and chromosomal aberrations can be easily missed. Since FISH plays...

objective(s) the main objective of this study was to investigate the status of chromosome stability in 3 human-mouse hybridoma cell lines over a period of time in various passages. materials and methods metaphase spreads from 3 human-mouse cell lines (hf2x653, spmo-4 and f3b6) that had been cultured in 4 successive passages, from 1 to 4 weeks, were prepared and analyzed. metaphase chromosomes s...

epilepsy is one of the most common neurological disorders. studies have demonstrated that genetic factors have a strong role in etiology of epilepsy. mutations in genes encoding ion channels, neurotransmitters and other proteins involved in the neuronal biology have been recognized in different types of this disease. moreover, some chromosomal aberration including ring chromosomes will result i...

background and objective: pregnancy termination and recurrent abortion are one of the common complications during pregnancy and in patients with a bad obstetric history. materials and methods: in this study, a total of 154 individuals including 75 couples four single women from different communities and with various incomes were investigated chromosomal abnormalities using blood culture and chr...

background: to study the outcome of cases with nuchal translucency (nt) ≥ 95th centile in the first trimester of pregnancy. methods: this cross sectional study was performed at iranian fetal medicine foundation (fmf) between january 2009 and december 2011. totally, 186 cases with nt≥ 95th centile who attended for the first trimester screening were studied. all cases with increased nt including ...

background: this study has used biomarker of exposure-effect continuum to examine the biological characteristics of organophosphate (op) toxicity and its genotoxic effect among rice farmers.   materials and methods : a cross-sectional study was conducted among 160 pesticide exposed rice farmers and 160 adults from the fishing village as the unexposed group. they share the common socio-economica...