Hepatitis B virus (HBV) and Hepatitis C virus (HCV) are the two most common blood borne, hepatotrophic viruses. HBV and HCV are important causes of liver related mortality and morbidity. Hepatitis B and hepatitis C are significant public health problems especially in developing countries like India. Hepatitis B was first reported in 1963 and hepatitis C in 1988 (Blumberg, 1997; Bonkovski et al....

background: hepatitis-c infection is a major problem in chronically transfused patients. we compared interferon-α (inf-α) monotherapy with combination of inf-α and amantadine in the treatment of β-thalassemia major patients who were chronically infected with hcv.materials and methods: forty six thalassemia major patients who were chronically infected with hcv were randomly divided into two grou...

background: recently, some new viruses have been identified for their association with hepatitis which torque teno mini virus being among them. the aim of this study was to determine the frequency of torque teno mini virus in healthy individuals and hepatitis b and c patients in isfahan, iran. materials and methods: one hundred serum samples of healthy individuals from isfahan blood transfusion...

BACKGROUND/AIMS Therapeutic vaccination is a new approach to treat patients with chronic hepatitis B virus infection. We have used the woodchuck model to examine the efficacy and safety of this approach. METHODS Seven woodchucks chronically infected with woodchuck hepatitis virus were immunized with surface antigen from this virus, purified from plasma, in conjunction with a peptide named FIS...

conclusions these results suggest that polymorphisms in interleukin-10 gene promoter influence clinical outcome of hbv infection and susceptibility to hbv infection. results persistent hbv infection was associated with il-10-1082 ag (p = 0.001) and gg (p = 0.004) genotypes and g (p = 0.000) allele. il-10-819 t/c and -592 a/c genotype and allele frequencies did not show any correlation with the ...

We compared the kinetics and magnitude of hepatitis B virus (HBV) infection in hepatitis C virus (HCV)-naive and chronically HCV-infected chimpanzees in whose livers type I interferon-stimulated gene (ISG) expression is strongly induced. HBV infection was delayed and attenuated in the HCV-infected animals, and the number of HBV-infected hepatocytes was drastically reduced. These results suggest...

Chronic hepatitis C virus (HCV) infection is associated with impaired proliferative, cytokine, and cytotoxic effector functions of HCV-specific CD8(+) T cells that probably contribute significantly to viral persistence. Here, we investigated the potential role of T cells with a CD4(+)CD25(+) regulatory phenotype in suppressing virus-specific CD8(+) T-cell proliferation during chronic HCV infect...

Undetectable hepatitis C virus (HCV)-specific RNA in serum six months after the end of treatment is the primary aim of antiviral therapy in patients with chronic hepatitis C. Long-term studies confirmed that viral eradication is durable in more than 95% of cases. The high chronification rate of acute hepatitis C (50 to 80%) justifies therapeutic strategies to prevent a chronic course of the inf...