نتایج جستجو برای: ciliary clearance
تعداد نتایج: 56320 فیلتر نتایج به سال:
In the present study, the lenses and ciliary bodies of 20 ostrich eyes were studied macroscopically and microscopically. The histological slides were studied after staining by hematoxylin and eosin, Verhoeff, Van Gieson, and periodic acid-Schiff (PAS). Posterior surface of lens was more convex than its anterior surface. The average lens diameter and thickness were respectively measured as 1.43 ...
nNOS regulates ciliated cell polarity, ciliary beat frequency, and directional flow in mouse trachea
Clearance of the airway is dependent on directional mucus flow across mucociliary epithelium, and deficient implicated in a range human disorders. Efficient relies proper polarization multiciliated cells sufficient ciliary beat frequency. We show that NO, produced by nNOS mouse trachea, controls both planar polarity frequency thereby necessary for generation robust flow. The effect ciliated its...
Primary ciliary dyskinesia (PCD) is characterized by the congenital impairment of mucociliary clearance. When accompanied by situs inversus, chronic sinusitis and bronchiectasis, PCD is known as Kartagener syndrome. The main consequence of impaired ciliary function is a reduced mucus clearance from the lungs, and susceptibility to chronic respiratory infections due to opportunistic pathogens, i...
Airway mucus hypersecretion and secretion retention can result from inflammation, irritation, stimulation, or mucus-producing tumors. Secretion clearance can be furthered hampered by ciliary dysfunction and by weakness or restrictive lung disease, leading to an ineffective cough. There are a number of different mucoactive medications that have been used to reduce hypersecretion, make secretions...
The integrity of healthy respiratory epithelium is maintained, at least in part, by trapping inhaled particles and microorganisms in a protective blanket of mucus which is transported towards the oropharynx by the coordinated action of the underlying ciliated cells. Ciliary dyskinesia is a recently recognised condition in which there is profound disturbance of this clearance mechanism because o...
Primary ciliary dyskinesia and Kartagener's syndrome are rare genetic disorders. There is a ciliary dysfunction in these disorders that cause recurrent infections in respiratory and sinus tracts associated with dextrocardia, chronic vasomotor rhinitis and dextrocardia. The aim of this paper is to report two rare cases of Primary ciliary dyskinesia, including one case of primary ciliary dyskin...
OBJECTIVE To study the effects of mycophenolate sodium on mucociliary clearance. INTRODUCTION Mycophenolate is one of the most commonly used immunosuppressive drugs in lung transplantation. Although its pharmacokinetic properties are well defined, its side effects on mucociliary clearance have not yet been studied. METHODS Sixty rats were subjected to left bronchial section and anastomosis....
Motile cilia of the lungs respond to environmental challenges by increasing their ciliary beat frequency in order to enhance mucociliary clearance as a fundamental tenant of innate defense. One important second messenger in transducing the regulable nature of motile cilia is cyclic guanosine 3',5'-monophosphate (cGMP). In this review, the history of cGMP action is presented and a survey of the ...
Primary ciliary dyskinesia is characterized by congenital impairment of mucociliary clearance. Kartagener syndrome (KS) is a clinical variant of primary ciliary dyskinesia which is involved in situs inversus associated with chronic respiratory infections. In addition, glomerular disease in KS syndrome is rare and reported cases are limited. We had a 27-year-old female patient with KS who presen...
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