Heat-shock protein 90 (Hsp90) promotes the maturation and stability of its client proteins, including many kinases. In doing so, Hsp90 may allow its clients to accumulate mutations as previously proposed by the capacitor hypothesis. If true, Hsp90 clients should show increased evolutionary rate compared to non-clients; however, other factors, such as gene expression and protein connectivity, ma...

Abstract Social workers use interventions in the expectation that they will make a positive difference for their clients. However, research about effectiveness of is typically presented at group level, which places great demands on social workers’ ability to apply such results needs individual Further, content and effects “service as usual” (SAU) offer are often not known, making it difficult i...

We study the problem of best arm identification in a federated learning multi-armed bandit setup with central server and multiple clients. Each client is associated which each yields i.i.d. rewards following Gaussian distribution an unknown mean known variance. The set arms assumed to be same at all define two notions local global. largest among client, whereas global average across assume that...

the notion of a $d$-poset was introduced in a connection withquantum mechanical models. in this paper, we introduce theconditional expectation of  random variables on thek^{o}pka's $d$-poset and prove the basic properties ofconditional expectation on this  structure.

While multisourcing offers benefits such as access to best-of-breed resources and enhanced competition, it also presents clients with a new governance challenge, namely the need ensure that vendors not only deliver their individual contributions but collaborate produce coherent joint outcome. Clients can address this challenge by combining bilateral focused on each vendor’s performance collecti...

background and objectives: hijama as a form of traditional medicine is used for treatment and prevention of diseases and maintenance of homeostasis. throughout the centuries it has been known as a national, cultural and religious form of therapy among iranian people and also the pillars of islamic practice and tradition. one of the common problems regarding this kind of therapy is that most pat...