نتایج جستجو برای: climbing mice
تعداد نتایج: 400064 فیلتر نتایج به سال:
The behavior of isolation-reared mice has not yet been studied in the staircase test. The present study examined the effects of anxiolytic or anxiogenic agents and isolation rearing on the behavior of ddY (outbred) strain mice in the staircase test. Diazepam and phenobarbital increased the number of steps climbed, but did not affect rearing behavior in group-reared mice. FG-7142, a benzodiazepi...
A longstanding but still controversial hypothesis is that long-term depression (LTD) of parallel fiber-Purkinje cell synapses in the cerebellum embodies part of the neuronal information storage required for associative motor learning. Transgenic mice in which LTD is blocked by Purkinje cell-specific inhibition of protein kinase C (PKC) (L7-PKCI mutants) do indeed show impaired adaptation of the...
BACKGROUND The hydro-ethanolic whole plant extract of Synedrella nodiflora (SNE) has demonstrated anticonvulsant, sedative and analgesic effects. Preliminary studies conducted in animals, SNE significantly decreased stereotypic behaviours suggesting antipsychotic potential. Coupled with the central nervous system depressant effects of SNE, we hypothesized that it may have utility in the managem...
Atherosclerosis is one of the most significant threats to health middle-aged and elderly people. The incidence rate atherosclerosis has been climbing its mechanism remains unclear. aim was determine role ankyrin repeat domain 36 in atherosclerosis. In mice aortic endothelial cells models stimulated by lipopolysaccharide, I found that Ankrd36 overexpression decreased expression inflammation fact...
Background Albizia zygia is used in Ghanaian traditional medicine for the management of mental disorders. The present study tested the hypothesis that an extract of the leaves of Albizia zygia (AZE) may possess antipsychotic and antidepressant properties. Method The novelty- and apomorphine-induced locomotor and rearing behaviours of AZE in mice were explored in an open-field observational te...
Cerebellar Purkinje cells are excited by two afferent pathways: climbing and mossy fibers. Climbing fibers evoke large "complex spikes" (CSs) that discharge at low frequencies. Mossy fibers synapse on granule cells whose parallel fibers excite Purkinje cells and may contribute to the genesis of "simple spikes" (SSs). Both afferent systems convey vestibular information to folia 9c-10. After maki...
Introduction: Major depressive disorder is often associated with suicidal tendencies, and this condition accentuates the need for rapid-acting antidepressants. We previously reported that alkaloids (ALK) from Trichilia monadelpha possess antidepressant action in acute animal models of depression and that this effect is mediated through the monoamine and L-arginine-NO-cGMP pathways. This study i...
OBJECTIVE To examine the effects of dehydroepiandrosterone (DHEA) on animal models of schizophrenia. METHODS Seventy Swiss albino female mice (25-35 g) were divided into 4 groups: amphetamine-free (control), amphetamine, 50, and 100 mg/kg DHEA. The DHEA was administered intraperitoneally (ip) for 5 days. Amphetamine (3 mg/kg ip) induced hyper locomotion, apomorphine (1.5 mg/kg subcutaneously ...
This research was done to test the effect of Rosa damascena essential oil on withdrawal signsof naloxone-precipitated morphine in male mice. Morphine dependence was induced by injection(IP) three times daily at doses of 50, 50 and 75 mg/kg, respectively, for 3 days. On day 4,after the last administration of morphine, Rosa damascena essential oil was administered atdifferent concentrations (5, 2...
چکیده آلکالوئیدهای ?– کربولین نظیر هارمان در مواد غذایی گیاهی معمولی( گندم، برنج، ذرت، جو، انگور و قارچ) و در مواد مشتق شده از گیاهانی نظیر توتون یافت می شوند. این آلکالوئیدها دارای اثرات شناختی زیادی از جمله تغییر در حافظه کوتاه مدت و بلند مدت و اثرات توهم زا می باشند. در این مطالعه نقش سیستم گلوتاماترژیک در هیپوکامپ پشتی بر روی اثرات هارمان بر حافظه اجتنابی مهاری مورد مطالعه قرار گرفته است. ...
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