Background : High microsatellite instability (MSI-H) colorectal carcinomas (CRCs) with numerous mutations in the microsatellite sequence are characterized by a right-sided preponderance, frequent peritumoral and intratumoral lymphocytic infiltration, and frequent mucin production. However, no study has correlated anatomic site and type of genetic changes with clinicopathologic changes. Methods ...

Abstract Introduction Gallbladder neoplasms are a rare pathology with an incidence of 1–2 cases per 100,000 inhabitants. In the group gallbladder neoplasms, adenocarcinoma is most common (95% total). Intracholecystic papillary neoplasm (ICPN) new entity considered to be premalignant lesion gallbladder. few published series, it found in 0.5–4% cholecystectomies and up 6% intracholecystic adenoca...

objective: to determine the role of global genome methylation in gastritis lesion and its relation with clinicopathologic finding. materials and methods: the study was conducted on 44 gastritis and normal adjacent specimens using a technique composed of restriction enzyme digestion and pyrosequencing known as luma (luminometric methylation assay). at first, dna extracted from gastritis lesion a...

We report detailed clinicopathologic features of 3 cases of plasmablastic lymphoma (PBL) with MYC/IgH rearrangement, representing one third of PBL cases diagnosed at our institution. This study brings the total number of reported cases in the literature to 6. All patients were HIV+ with very low CD4 counts at diagnosis. The involved locations were mediastinum, anus, and bone marrow. Tumors exhi...

Reports on clinical and histologic follicular alterations in patients previously diagnosed with mycosis fungoides (MF) or at the time of MF diagnosis are rare. The clinical and histologic criteria to distinguish MF associated with follicular mucinosis from follicular MF are a matter of debate. A patient is described with advanced clinical and histologic alterations predominated by follicular le...

157 Session editor: Alfredo José Mansur Associate editors: Desiderio Favarato Vera Demarchi Aiello Mailing address: Alfredo José Mansur InCor Av. Dr. Enéas C. Aguiar, 44 05403-000 São Paulo, SP, Brazil English version by Stela Maris C. Gandour Case 4/2000 – Heart failure in a 9-year-old child after treatment with anthracycline for Wilms’ tumor (Instituto do Coração of Hospital das Clínicas FMUS...

Introduction: The presence of HER-2 has been shown to be a prognostic factor in many kinds of cancers, but its role in head and neck squamous cell carcinoma (HNSCC) is not still defined. The purpose of the current study is to investigate the role of HER-2 in HNSCC and its correlation with various clinicopathologic parameters.   Materials and Methods: Peripheral blood samples were obtained ...