Pharmaceutical co-crystal formation represents a straightforward way to dramatically influence the solid-state properties of a drug substance, particularly its solubility and hence bioavailability. This short review summarises this highly topical field, covering why the topic is of interest in pharmaceutical formulation, the definitions and practical scope of co-crystals, co-crystal preparation...

Abstract One of the basic assumptions in hub covering problems is considering the covering radius as an exogenous parameter which cannot be controlled by the decision maker. Practically and in many real world cases with a negligible increase in costs, to increase the covering radii, it is possible to save the costs of establishing additional hub nodes. Change in problem parameters during the pl...

Let π1 : K H , π2 : H G and π2π1 : K G be three finite regular coverings of graphs, and let σ be a representation of the covering transformation group of π1. We show that the L-function of G associated to the representation of the covering transformation group of π2π1 induced from σ is equal to that of H associated to σ by means of ordinary voltage assignments. © 2003 Elsevier Science Ltd. All ...

If M is compact Kählerian and ρ is semi-simple, that is that the Zariski closure of the image of ρ in GL(n,C) is semi-simple 1, by means of a result of Donaldson (in the case of Riemann surfaces, [5]) and Corlette (in the higher dimensional case, [4]), there exists a unique harmonic metric u on V, equivalently, a ρ-equivariant harmonic map from the universal covering M̃ of M into Pn := GL(n,C)/U...

In this paper, we define the fundamental group of a topological space and explore its structure, and we proceed to prove Van-Kampen’s Theorem, a powerful result useful for calculating the fundamental groups of spaces which decompose into spaces whose fundamental groups are already known. With these tools, we show that the circle, 2-sphere, torus, and figure-8 space are topologically distinct. W...

We use reformulation techniques to model and solve a complex sphere covering problem occurring in the configuration of a gamma ray machine radiotherapy equipment unit.