BACKGROUND Some poorly differentiated thyroid carcinomas (PDTC) arise from pre-existing, well-differentiated carcinomas of follicular cell origin; however, others most likely arise de novo. The case of a PDTC adjacent to a pre-existing nodular goiter is very rare. CASE PRESENTATION A patient had a PDTC, a widely invasive, cellular tumor with cells that lacked the nuclear features of a papilla...

Background: The recent development of attenuated total internal reflectionFourier transform infrared (ATR-FTIR) spectroscopy has provided a new avenue for distinguishing cancerous tissue from normal one. The focus of this investigation is to develop a novel spectral discriminant method for thyroid malignant and benign samples, intraoperatively. Methods: A total of 112 cases of human thyroid tis...

Since first discovered just 35 years ago, the incidence of spontaneous feline hyperthyroidism has increased dramatically to the extent that it is now one of the most common disorders seen in middle-aged to senior domestic cats. Hyperthyroid cat goiters contain single or multiple autonomously (i.e. TSH-independent) functioning and growing thyroid nodules. Thus, hyperthyroidism in cats is clinica...

A 45-year-old female presented with symptoms of hyperthyroidism and hot nodules in the right lobe, which was diagnosed as nodular goiter by fine-needle aspiration. An anomalous thyroidectomy and difficult dissection with multiple rotations were performed around the trachea. As a remark, the pathology confirmed the presence of goiter with modular nodules (Figure 1). A macroscopic photograph show...

PURPOSE The aim of this investigation was to quantitatively evaluate C-cells in colloid goiters, analyzing 36 thyroids that were obtained through thyroidectomy from 24 patients with goiter and 12 normal glands from adult patients without thyroid disease, which were used as the control group. MATERIAL AND METHODS On average, 6 different thyroid areas were sampled and labeled by immunohistochem...

Congenital defects in thyroglobulin (Tg) synthesis in animals have proven to be useful models for the study of Tg synthesis and regulation. Defects in Tg synthesis have been well described in Afrikander cattle, Australia Merino sheep, and goats in The Netherlands. This report describes a study of goiter in a nondomesticated bovine species, bongo antelope (Tragelaphus eurycerus), an African bovi...

Non-neoplastic thyroid lesions include nodules with nondiagnostic cytology and those benign cytology. In approximately 15% of cases, fine-needle aspiration (FNAC) results in cytologically inadequate specimens. Nondiagnostic smears have an number cells to allow a diagnosis. This category also includes cystic lesions, which are frequent cause results. Benign diagnosis represents the most result f...

UNLABELLED Vascular endothelial growth factor (VEGF) is a critical regulator of angiogenesis and is involved in tumor development. To date, the role of VEGF in benign diseases of the thyroid is not well known. The purpose of the present study is to determine the expression of VEGF and its receptors in primary cultures of human thyrocytes. METHODS 50 patients with uninodular (n=11), multinodul...

OBJECTIVE To summarize the experience in the peri-operative treatment of giant nodular goiter. METHODS A total of 123 patients with giant nodular goiter sized 6~20 cm were admitted into our hospital from 1990 to 2011 and the clinical data were retrospectively analyzed. These patients underwent total or subtotal thyroidectomy. RESULTS All patients underwent surgical intervention. Unilateral ...