introduction although thyroid nodules are usually benign, malignancy must always be ruled out. many efforts have been made to find. malignant nodules and reduce the number of unnecessary operations. in this study, our aim was to examine, after the more extensive use of fine needle aspiration (fna), whether the incidence of cancer finding has been increased. materials and methods we studied retr...

Background: The normal thyroid gland is a fairly homogenous structure, but nodules often formed within its substance these nodule may be the growth and fusion of localized colloid – filled follicles, or discrete adenomas, or cyst. The terms adenomatous goiter, simple multi nodular goiter, non toxic nodular goiter, and colloid nodular goiter are used interchangeably as descriptive terms when a m...

Hashimoto’s Thyroiditis is common cause of hypothyroidism with goiter in Iodine sufficient regions due to chronic auto immune disease. Patients with Hashimoto’s Thyroiditis present either a small diffuse goiter or markedly enlarged firm gland mimicking malignancy. These patients may have an associated dominant nodule, most commonly a benign colloid, adenomatous nodule, nodular thyroiditis, or a...

A middle-aged female with a goiter of 10 years' duration presented with progressive pressure symptoms, nocturnal choking and dyspnea on exertion for 5 months. Physical examination demonstrated a large simple multinodular goiter. Imaging revealed a deep retrosternal goiter extending below the tracheal bifurcation with marked tracheal deviation. Total thyroidectomy was carried out via a cervical ...

OBJECTIVE The relative expression of the apoptotic protein Fas and the anti-apoptotic protein Bcl-2 were investigated in thyrocytes from patients with non-toxic nodular goiter (NTG, n=20) and Hashimoto's thyroiditis (HT, n=5), who underwent fine-needle aspiration biopsy for diagnostic reasons. On the basis of the clinical and cytological findings, the patients with NTG were sub-classified into ...

Objective. It has been testified that iodine regulates thyroid function by controlling thyroid-restricted genes expression and is closely related to diffuse goiter and thyroid dysfunction. However, the effects of follicular lumen iodine, the main form of iodine reserve in the body, on thyroid-restricted genes in nodular goiter are poorly understood. In this study, correlations between follicula...

INTRODUCTION Levothyroxine (LT4) therapy has been used for the treatment of euthyroid nodular goiter, but there are controversial results about its usefulness. We aimed to evaluate the possible role of benign nodules' cytological characteristics in response to LT4 therapy. MATERIAL AND METHODS In total, 93 patients with 128 nodules were included in the study; 74 of the nodules were treated wi...

OBJECTIVE To describe quantitative cytophotometric expression of the marker caspase-3 in colloid goiter and in papillary carcinoma of the thyroid, comparing the immunoexpression between them. METHODS An immunohistochemistry study has been made on the protein caspase-3 in 17 of paraffin blocks of papillary carcinoma of the thyroid and 20 cases of colloid goiter, using SAMBA 4000 ® (System of M...