BACKGROUND Dengue fever and leptospirosis have partially overlapping geographic distributions, similar clinical presentations and potentially life-threatening complications but require different treatments. Distinguishing between these cosmopolitan emerging pathogens represents a diagnostic dilemma of global importance. We hypothesized that perturbations in host biomarkers can differentiate bet...

This study described the clinical features and complications of leptospirosis among patients seen at nine tertiary hospitals from September 28 to November 30, 2009 after a heavy rainfall typhoon. The clinical findings of the confirmed cases were compared with the previous clinical studies on seasonal leptospirosis in the Philippines. Risk factors for complicated disease were also identified. Co...

BACKGROUND Severe leptospirosis is frequently complicated by a hemorrhagic diathesis, of which the pathogenesis is still largely unknown. Thrombocytopenia is common, but often not to the degree that spontaneous bleeding is expected. We hypothesized that the hemorrhagic complications are not only related to thrombocytopenia, but also to platelet dysfunction, and that increased binding of von Wil...

Background: Leptospirosis is characterized by very diverse clinical manifestations, which may range from flu-like subclinical forms to very severe presentations characterized by multi-organ failure, or to atypical presentations. One of its most aggressive presentations is Weil’s disease, characterized by jaundice, hemorrhagic phenomena and renal failure. Cases with high bilirubinemia over 30mg/...

Malaria and leptospirosis are both common in the tropics. Simultaneous infections are possible, although not previously reported. We report two cases of malaria from an area of Thailand on the Thailand-Myanmar border with compelling serologic evidence of simultaneous acute leptospirosis. One was a case of infection with Plasmodium falciparum with acute and convalescent microscopic agglutination...

BACKGROUND Pulmonary involvement in leptospirosis remains poorly recognized in regions where it is endemic, despite reports of recent outbreaks and epidemic disease. METHODS A prospective, population-based study was carried out to identify febrile patients exposed to Leptospira in urban and rural contexts in Iquitos, Peru. Evidence of exposure to Leptospira was obtained by serologic testing, ...

Leptospirosis occurring in a husband and wife is described. Both were responsible for cleaning up the excreta of a recently acquired puppy. The wife developed leptospirosis canicola, and three months later the husband developed leptospirosis icterohaemorrhagica. Difficulty was experienced in ascertaining the infecting species of leptospire in the husband owing to the agglutination tests giving ...

Leptospirosis is one on those many diseases which expresses itself in the form of outbreaks associated with seasonal variations like rainfall. Pathogenic organism responsible for this disease is a spirochete of genus Leptospira which exists in around 300 serovars.[3] Leptospirosis presents itself in a wide spectrum of clinical presentations frequently mimicking other diseases, so frequently it ...

Leptospirosis in pregnancy is often underdiagnosed and not commonly reported due to its unusual appearance rarity. It looks like HELLP syndrome, obstetric cholestasis, viral hepatitis & pregnancy-related acute fatty liver. Miscarriages the first trimester, stillbirths, neonatal leptospirosis are serious complications that necessitate a high degree of concern, heightened sensitivity, prompt ...