Background and Objective: In this research, the effect of chronic dietary soybean aqueous extract on aortic reactivity of streptozotocin (STZ)-diabetic rats was investigated. Materials and Methods: STZ-diabetic rats were treated with soybean aqueous extract for two months after diabetes induction. Contractile reactivity to KCl and phenylephrine (PE) and relaxation response to acetylcholine (ACh...

The present study was undertaken to determine whether two-month treatment of streptozotocin (STZ)-diabetic rats with aqueous leaf extract of Trigonella foenum-graecum (TFG 200 mg/kg i.p.) could improve thoracic aortic responsiveness and to evaluate its endothelium dependency. For this purpose, vascular responses to KCl and noradrenaline (NA) were measured. Diabetic state significantly increased...

Background: Diabetes is an important risk factor for cardiovascular events. Endothelial dysfunction is the main reason cause of disability and death in diabetic patients and death. The present study investigates the effects of metformin and glibenclamide on vasoconstrictive and vasodilative responses in the diabetic rat aorta. Methods: Rats were divided into four experimental groups (con...

background and objective: in this research, the effect of chronic dietary soybean aqueous extract on aortic reactivity of streptozotocin (stz)-diabetic rats was investigated. materials and methods: stz-diabetic rats were treated with soybean aqueous extract for two months after diabetes induction. contractile reactivity to kcl and phenylephrine (pe) and relaxation response to acetylcholine (ach...

the present study was undertaken to determine whether two-month treatment of streptozotocin (stz)-diabetic rats with aqueous leaf extract of trigonella foenum-graecum (tfg 200 mg/kg i.p.) could improve thoracic aortic responsiveness and to evaluate its endothelium dependency. for this purpose, vascular responses to kcl and noradrenaline (na) were measured. diabetic state significantly increased...

atp-sensitive potassium (katp) channel openers have a relaxation effect due to the lower cellular membrane potential and inhibit calcium influx. there has been considerable interest in exploring katp channel openers in the treatment of various diseases such as cardiovascular, cerebrovascular, and urinary system disease and premature labor. the purpose of this study was to synthesize 3,3,6,6-tet...

BACKGROUND Chronic dysfunctional but viable myocardium may exhibit contractile reserve and/or intact perfusion. Segments with intact perfusion without contractile reserve are frequently observed inpatients with ischemic cardiomyopathy. The clinical relevance of this observation is unclear; in particular, the functional outcome after revascularization is unknown. Thus, contractile reserve (using...

Objective: Diabetes is an important risk factor for cardiovascular events. The great percent of morbidity in patients with diabetes is due to endothelial dysfunction. The present study investigated the effects of hydroalcholic extract of Nigella sativa (N. sativa)  on contractile and dilatation response of isolated aorta in streptozotocin (STZ)-induced diabetic rat. Materials and Methods: Rats ...