mal thickness of 41.1 μm, whereas sites treated with vehicle alone measured an average of 22.6 μm, indicating a significant difference in epidermal thickness between aTd-treated groups and vehicle controls, Po0.001 (Mann– Whitney test, Figure 1e and f). In summary, we have demonstrated in vivo capabilities of aTds to initiate protect and repair response in non-UVexposed guinea pig skin. By mimi...

INTRODUCTION Lamellar Ichthyosis is an autosomal recessive, inherited skin disorder characterized by thickening, fissuring and scaling of the skin. OBJECTIVE To report a case of lamellar icthyosis and highlight the importance of monitoring corneal health in these patients. CASE We report a rare case of bilateral spontaneous corneal perforation in a patient with lamellar ichthyosis .The pati...

The morphologic appearance and time course of regenerating rabbit corneal epithelium was studied after 6.0 mm. corneal abrasions. The immediate response to injury was separation and thickening of basal and squamous epithelial cells at and near the wound margin. A variable number and distribution of polymorphonuclear leukocytes appeared on the basal lamina and regenerating epithelial edge at 3 h...

Fuchs endothelial corneal dystrophy (FECD) is the most common late-onset, vision-threatening corneal dystrophy in the United States, affecting about 4% of the population. Advanced FECD involves a thickening of the cornea from stromal edema and changes in Descemet membrane. To understand the relationship between FECD and central corneal thickness (CCT), we characterized common genetic variation ...

The aim of the study was the presentation of changes in thickness of each layer of a developing cornea, that came into being under an influence of caffeine which was administered to chicken embryos. Research materials were 26 chicken embryos from breeding eggs that had been incubated. Breeding eggs were divided into two groups: control (n=30) in which Ringer liquid was given, and experimental (...

Fuchs endothelial corneal dystrophy (FECD) is a leading indication for corneal transplantation. FECD is characterized by progressive alterations in endothelial cell morphology, excrescences (guttae) and thickening of the endothelial basement membrane and cell death. Ultimately, these changes lead to corneal edema and vision loss. Due to the lack of vision loss in early disease stages and the de...

patients with mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (melas) present with recurrent and partially reversible neurological deficits. lesions of melas classically cause a signal change in both the grey and white matter, predominantly in the occipital and parietal lobes. these lesions mimic infarction. here, we reported a case of melas with rare neuroimaging finding...

PURPOSE To determine and correlate epithelial corneal thickness (pachymetric) measurements taken with a digital arc scanning very high frequency ultrasound biomicroscopy (HF UBM) imaging system (Artemis-II), and compare mean and central epithelial thickness among normal eyes, untreated keratoconic eyes, and keratoconic eyes previously treated with collagen crosslinking (CXL). METHODS Epitheli...

The present study aims to clarify corneal development via analyzing of the histomorphologic and some histochemical parameters in local rabbits. Samples were collected from 25 Rabbits divided into five different age groups at 1, 10, 15, 30, 40 postnatal day (PND), then samples sectioned, processed, stained with Hematoxylin eosin stain Masson’s trichrome stain. Some sections further periodic acid...