purpose: to evaluate the efficacy of riboflavin administration and ultraviolet a (uva) cross-linking on advanced symptomatic bullous keratopathy (bk). methods: 10 patients with symptomatic pseudophakic bullous keratopathy (pbk) were included. slit-lamp examination, visual acuity, foreign body sensation (fbs) and corneal thickness as measured by pentacam, were performed before corneal cross-link...

purpose: to report the histopathological diagnoses of recipient corneal buttons in patients undergoing penetrating keratoplasty. methods: in this observational case series, all recipient corneal specimens sent to the ophthalmic pathology laboratory of the eye bank of iran between 2004 and 2007 underwent histopathologic examination. results: overall, 315 corneal specimens were evaluated. histopa...

PURPOSE To investigate the time course of corneal thickness changes in overnight hyperopic orthokeratology (OK) lens wear for a 4-day lens-wearing period. METHODS Fourteen subjects (age range, 20-37 years) were fitted with hyperopic OK lenses in one eye only. The fellow eye acted as a non-lens wearing control. Lenses were worn overnight only for 4 nights, and changes from baseline in subjecti...

Purpose. To evaluate the changes in epithelial thickness profile following transepithelial photorefractive keratectomy (T-PRK) for myopia and to investigate the effect of epithelial remodeling on corneal asphericity. Methods. Forty-four patients (44 right eyes) who underwent T-PRK were retrospectively evaluated. Epithelial thickness was measured using spectral-domain optical coherence tomograph...

PURPOSE To investigate the changes in the epithelium and flap after laser in situ keratomileusis (LASIK), when measured with optical coherence tomography (OCT). METHODS Twenty-eight eyes of 14 patients (age: 39.9 +/- 8.6 years) underwent LASIK. The central thickness of corneal epithelium and flap were measured with a real-time 1310 nm OCT 1 day, 1 week, and 1 month after surgery. A custom sof...

Vasoactive and mitogenic peptide, endothelin-1 (ET-1) plays an important role in physiology of the ocular tissues by regulating the growth of corneal epithelial cells and maintaining the hemodynamics of intraocular fluids. We have previously established that ET-1 can be degraded in vivo by two lysosomal/secreted serine carboxypeptidases, Cathepsin A (CathA) and Serine Carboxypeptidase 1 (Scpep1...

A unique kindred manifesting medullary thyroid carcinoma and corneal nerve thickening without other aspects of the multiple endocrine neoplasia syndrome (MEN) was analyzed by linkage analysis using four highly polymorphic (CA)n repeat markers (sTCL-1, D10S141, ZNF22, and sJRH-1). Additionally, the RET protooncogene was examined for specific mutations by DNA sequence analyses in all affected fam...

PURPOSE To study the corneal epithelial and stromal thickness profile changes after photorefractive keratectomy (PRK) for myopia. METHODS Retrospective analysis of the postoperative corneal epithelial and stromal thickness profile changes in 46 left eyes of 46 patients treated with PRK for myopia. Corneal and epithelial thickness maps within the central 6 mm were obtained by anterior segment ...

PURPOSE To investigate changes in corneal topography and morphology in human eyes wearing orthokeratology (OK) lenses for overnight and over a 5-year period. MATERIALS AND METHODS Fifty-six adults with moderate myopia were assigned to 2 groups based on age matching: 5-year lens wear (n = 26, 51 eyes) and 1-night lens wear (n = 30, 60 eyes). All subjects wore reverse-geometry OK lenses with th...

PURPOSE To report the long-term clinical outcome of a patient diagnosed as having Terrien marginal degeneration (TMD) who was subjected to corneal collagen cross-linking (CXL) with ultraviolet-A and riboflavin in both eyes. METHODS Topographical changes were assessed by high-resolution Scheimpflug imaging and anterior segment optical coherence tomography. Eccentric epithelium-off CXL was perf...